Diflunisal

Analgesics. Four examples of antiinflammatory agents are Sulindac [38194-50-2] based on a monofluoro indene derivative diflunisal... [Pg.269]

FLUOROBIPHENYLS Fluorobiphenyls are incorporated into the analgesic and antiinflammatory dmgs diflunisal [22494-42-4] and flurbiprofen [5104-49-4]. The first is a difluoro compound and the other monofluoro. [Pg.328]

Fluormated agents such as flurbiprofen (II), flunisal(i2), diflunisal (13), and sulindac (14), acting as prostaglandin synthesis mhibitors, have been available for some time [5] The recent introduction of flunoxaprafen (15), a lipoxygenase inhibitor, is notable It reportedly produces considerably less severe gastric disturbance [75]... [Pg.1121]

Salicylic acid for systemic use has been replaced by acetylsalicylic acid, amides of salicylic acid (salicylamide, ethenzamide, salacetamide), salsalate and diflunisal. [Pg.874]

Reduction of elevated body temperature (except for diflunisal which is not used as an antipyretic) ... [Pg.151]

Aspirin, sodium salicylate, choline magnesium trisalicylate, salsalate, diflunisal, salicylsalicylic acid, sulfasalazine, olsalazine... [Pg.172]

Salicylic acid analogues are often active as nonsteroidal antiinflammatory agents because they interfere with biosynthesis of prostaglandins. Diflunisal (3) appears to be such an agent. It is synthesized from the nitrobiphenyl 1 by catalytic reduction to... [Pg.85]

Fig. 10 Differential scanning calorimetry thermograms obtained for diflunisal, form I (lower trace) and form II (upper trace).

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