Fluormating agents

Fluormating Agent Method of Pi eparation Yield (%) Properties Ref... 

Fluormated agents such as flurbiprofen (II), flunisal(i2), diflunisal (13), and sulindac (14), acting as prostaglandin synthesis mhibitors, have been available for some time [5] The recent introduction of flunoxaprafen (15), a lipoxygenase inhibitor, is notable It reportedly produces considerably less severe gastric disturbance [75]... 

The mixture was kept at 40-50 °C for 3 h and then overnight at room temperature Dibenzyl ether (25%) was isolated Nitrobenzyl fluorides are obtained by adding the alcohol to an excess of the fluormating agent When hexafluoropropyldiethylamine is added to the alcohol, dibenzyl ethers are formed exclusively ... 

Fluormated secondary alcohols are easily oxidized to the eorresponding ketones This reaction is earned out with a vanety of agents... 

The introduction of fluonne into anh-mfective agents has produced a number of products The fluormated qumolone anUbactenals, as a group, are characterized by low incidence of side effects and cure rates as high as 90% There are presently six commercial products of general stracture 1, two of which are shown... 

The role of fluorine in the development of CNS agents has been reviewed [14] Fluormated phenotluazines, typified by fhiphenazine (1 ) are more potent than chlorpromazine m the management of severely disturbed psychotic patients [14] The butyrophenones, of which haloperidol (7 7) is the oldest example, are typically 50 times more potent than chlorpromazine Pimozide (18) is an example of the diarylbutylammes, which are potent neuroleptics [I4 ... 

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