3,3 - diacetic acid

Compounds of the type RO—Y—OR, where the two parent compounds are identical and contain a group having priority over ethers for citation as suffix, are named as assemblies of identical units. For example, HOOC—CH2—O—CH2CH2—O—CH2—COOH is named 2,2 -(ethylene-dioxy)diacetic acid. 

Carbamylphenylarsylenedithio)diacetic acid [531-72-6] M 345.1, pKes, 3.5. Crystd from MeOH or EtOH. 

The copper-catalyzed decomposition of diazoacetic ester in the presence of pyrrole was first described in 1899 and later investigated in more detail by Nenitzescu and Solomonica. Ethyl pyrrole-2-acetate (13), the normal product of electrophilic substitution, was obtained in 50% yield and was degraded to 2-methylpyrrole. Similarly iV -methylpyrrole with two moles of diazoacetic ester gave, after hydrolysis, the 2,5-diacetic acid (14) while 2,3,5-trimethylpyrrole gave, after degradation, 2,3,4,5-tetramethylpyrrole by substitution of ethoxycarbonylcarbene at the less favored )3-position. Nenitzescu and Solomonica also successfully treated pyrroles with phenyl-... 

Jackson and Manske described the decomposition of diazoacetic ester with indoles to give, after hydrolysis, the 3-acetic acid and some 1,3-diacetic acid no product of 2-substitution was found (see also ref. 49). Diazoacetone and diazopyruvic ester similarly gave the 3-sub-stituted indoles.Badger et al. have also examined the reaction of iV -methylindole, as well as of indole, with diazoacetic ester. Again only the 3-substituted product resulted and no evidence was obtained for addition. 

Several cyclic glyphosate analogs related to this series were described previously as intermediates to prepare glyphosate. These include various N-phosphonomethylhydantoins and diketopiperazines. A more extended glyphosate piperazine analog 106 has also been prepared firom the Mannich reaction of ethylenediamine-lV,lV -diacetic acid (65). 

The Cr(II)-catalysed substitution reaction between Cr(III) and A-methylimino-diacetic acid HjL... 

Aromatic polyesters were efficiently synthesized from aromatic diacid divinyl esters. Lipase CA induced the polymerization of divinyl esters of isoph-thalic acid, terephthalic acid, and p-phenylene diacetic acid with glycols to give polyesters containing aromatic moiety in the main chain. The highest molecular weight (7.2 x 10 ) was attained from a combination of divinyl isophthalate and 1,10-decanediol. Enzymatic polymerization of divinyl esters and aromatic diols also afforded the aromatic polyesters. ... 

Tris(hydroxymethyl)methylimino-N,N-diacetic acid TRIDA... 

N- 3-Hydro)q ropyl)imino-N-N-diacetic acid Amidoiminodiacetic acid... 

Miyahara, T., Kitamura, H., Narita, K., and Toyo oka, T., Ion-exchange chromatography of aluminum using 3-carboxy-2-naphthylamine-N,N-diacetic acid as a fluorescent post-column chelating reagent, Biomed. Chromatogr., 13, 70, 1999. 

Analogously prepared are the diesters of TV-methyl-phenothiazine diacetic acid and mono-/7-toluenesulfonyl-, chloro- or iodooligoethylene glycols.[144]... 

C NMR studies suggest that 1,4,7,10-tetra-azacyclododecane-l,7-diacetic acid binds to zinc in a cis octahedral geometry—the two carboxylate oxygens are cis and the remaining four donors from the cyclen macrocycle. The formation constant was determined for the complex.733... 

As early as 1996, Nelson and Miller (1996) reported initial successful experiments. They synthesized AEG and small amounts of ethylenediamine diacetic acid from mixtures containing ethylenediamine, formaldehyde and HCN thus the formation of AEG (Fig. 6.12) is possible via the Strecker synthesis (see Sect. 4.1). 

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