Diethylcarbamoyl chloride

JHC787), N,A -diethylcarbamoyl chloride the amide 170 (95T10969), and, contrary to earlier reports, DMF gives the 7-formyl derivative 171 (95JHC787). 

The submitters used diethylcarbamoyl chloride from Aldrich Chemical Company, Inc., after fractional distillation. The checkers used the reagent without further purification with similar results. 

Chromosomal analysis of peripheral lymphocytes from 10 people who had been occupationally exposed to dimethylcarbamoyl chloride (and diethylcarbamoyl chloride) for periods ranging from 4 to 17 years showed differences in the frequency of chromosomal aberrations (inclusive and exclusive gaps), when compared with a control group of 10 people matched for age, although statistical evaluation revealed no significant increase (Fleig Thiess, 1978). 

Fleig, I. Thiess, A.M. (1978) Chromosome investigations of persons exposed to dimethy Icarba-moyl chloride and diethylcarbamoyl chloride. J. occup. Med., 20,745-746... 

Azine oxides are versatile starting materials for heterocyclic synthesis and are frequently used for regioselective ring substitution reactions, most of which proceed with loss of the oxide substituent. Occasionally some unusual selectivities are observed. For example, treatment of 3-methoxypyrazine A-oxide with equimolar amounts of diethylcarbamoyl chloride and 4-methoxytoluene-a-thiol in refluxing acetonitrile gave 2-methoxy-6-(4-methoxybenzylthio)-pyrazine as the sole product in 60% yield. 

The starting point for the metallation sequence was /7-chlorophenol, whose directing power was first maximised by conversion to the carbamate 3. Ortholithiation and reaction with N,N-diethylcarbamoyl chloride gave the amide 4. The second ortho carbonyl substituent was then introduced simply by allowing the lithiated carbamate 5 to undergo an anionic ortho-Fries rearrangement to the bis-amide 6. The phenol was protected as its methyl ether 7. 

Reaction of isoquinoline, potassium cyanide, and N,iV-diphenyl-carbamoyl chloride gave 67. A similar compound was also obtained through the use of A,iV-diethylcarbamoyl chloride. Again the infrared... 

DIETHYLCARBAMOYL CHLORIDE see DIW400 N,N-DIETHYLCARBAMOYL CHLORIDE see DIW400 l-DIETHYLCARBAMOYL-4-METHYLPIPERAZINEsee DIWOOO... 

An application of the nickel catalysis is shown here in the formation of 2,7-disubstituted derivatives of naphthalene, which are less common in the library of commercial fine chemicals. For these reasons, the submitters developed some synthetic routes to 2,7-bis(diethylcarbamoyloxy)naphthalene, 2,7-dimethylnaphthalene4 and 2,7bis(bromomethyl)naphthalene that will facilitate access to a large family of 2,7-disubstituted naphthalenes.5 The low cost of N,N-diethylcarbamoyl chloride, relative to triflic anhydride (for making aryl triflates), allows... 

N,N-Diethylcarbamoyl chloride was used as received from Aldrich Chemical Company, Inc. (99%) or Tokyo Chemical Industry Co. (>95%). It was transferred to the dropping funnel via a syringe. 

Diethylcarbamoyl chloride Cancer Suspect Agent Carbamic chloride, diethyl-(8,9) (88-10-8)... 

A7,iY-DiethylcarbarnoyIjindolo (385) can be prepared by the action of diethylcarbamoyl chloride on indole magnesium iodide.69... 

Preparation of a series of substituted benzo[6]thiophen-2-ones 18 (separable mixtures of (E) and (Z) isomers) from the thiocarbamate 19 and aldehydes has been reported. The starting compound 19 was obtained by reaction of 2-methylthiophenol 20 with A(Af-diethylcarbamoyl chloride <04H(63)1813>. 

A. 2,7-Bis(diethylcarbamoyloxy naphthalene,2 Into a dry, 1-L, three-necked, round-bottomed flask, equipped with a mechahical stirrer and a condenser, are added 2,7-dihydroxynaphthalene (49.7 g, 0.310 mol, Note 1) and pyndine (700 mL, Note 2) under nitrogen. A dry, 200-mL pressure-equalizing dropping funnel fitted with a rubber septum is installed and charged with N,N-diethylcarbamoyl chloride (120 mL, 0.900 mol Note 3). After the reaction flask is cooled in an ice bath for 30 min, N.N-diethylcarbamoyl chloride is added within S min to the vigorously stirred mixture. The Ice bath is removed and the dark-brown solution is warmed to room temperature. The dropping funnel Is removed under a stream of nitrogen and a thermometer is installed. 

Turnkey Process for Celiprolol Celiprolol has a unique Af,Af-diethylurea in its structural framework we wished to integrate HKR into a process. The existing route starts with 4-ethoxyaniline which was treated with diethylcarbamoyl chloride in the presence of potassium bicarbonate to give A -p-ethoxyphenylacetamide (Scheme 30.7). Friedel-Crafts acylation with acetyl chloride and anhydrous aluminum chloride followed by acid hydrolysis furnished the acetophenone derivative. Reaction of the urea derivative with epichlorohydrin followed by treatment with hydrobromic acid yielded a bromohydrin. Celiprolol was obtained as a free base by reaction of this bromohydrin with feri-butylamine in the presence of triethylamine, and was later converted to its hydrochloride salt. 

The introduction of MA -diethylurea is carried out at a fairly early stage of the process with an expensive reagent, diethylcarbamoyl chloride (DECC). Being labile, this unit... 

The discovery of the A-cumyl directed metalation group (DMG) for amides, 0-carbamates, and sulfonamides helps to broaden the scope of new DoM strategies. Synthetic utility is demonstrated by establishing viable routes to 4- and 4,7-substituted saccharin derivatives (eq 50). Thus, BuLi/TMEDA metalation of selected biaryl A -cumylsulfonamides followed by M(Y-diethylcarbamoyl chloride quench results in a regioselective functionalization (eq51). 

In 1985, Snieckus et al. reported another method for the preparation of racemic ochratoxin a (326) and its dechloro analog 331 in only four steps (269). They used the readily accessible 0-aryl carbamates 333a and 333b (270) as starting materials for their synthesis (Scheme 6.2). The 0-carbamate benzamides 334a and 334b were obtained by metalation of the carbamates followed by quenching with diethylcarbamoyl chloride. The next step consisted of a 1,3-carbamoyl... 

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