Celiprolol hydrochloride

Celectol celiprolol esmolol. celiprolol [ban, inn, usan] (Celectol ) is a P-adrenoceftor antagonist, which is relatively water-soluble. It can be used therapeutically in ANTlANGiNAL and hypertensive treatment, celiprolol hydrochloride celiprolol. 

Celiprolol hydrochloride is a once-dedly, cardioselective g-adrenergic blocker useful in the management of hypertension, angina pectoris and hyperkinetic heairt syndrome. It is also being evaluated in glaucoma. 

Celectol (Celiprolol hydrochloride). Winlhrop Pharmaceuticals UK Ltd. UK Summary of product characteristics, September 2004. 

Turnkey Process for Celiprolol Celiprolol has a unique Af,Af-diethylurea in its structural framework we wished to integrate HKR into a process. The existing route starts with 4-ethoxyaniline which was treated with diethylcarbamoyl chloride in the presence of potassium bicarbonate to give A -p-ethoxyphenylacetamide (Scheme 30.7). Friedel-Crafts acylation with acetyl chloride and anhydrous aluminum chloride followed by acid hydrolysis furnished the acetophenone derivative. Reaction of the urea derivative with epichlorohydrin followed by treatment with hydrobromic acid yielded a bromohydrin. Celiprolol was obtained as a free base by reaction of this bromohydrin with feri-butylamine in the presence of triethylamine, and was later converted to its hydrochloride salt. 

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