Diethyl acetylation

The reaction of diethyl acetyl- and propionylmalonates with hydroxyl-amine hydrochloride or its N-methyl derivative in ethanol afforded the appropriate ethyl 3-alkyl-2,5-dihydro-5-oxo-4-isoxazolecarboxylate (88-TL6339). 

The stereoselective Michael addition of the anion derived from diethyl acetyl-aminomalonate with chalcone has been found to be most effective under soliddiquid two-phase conditions in the absence of an added solvent [62]. For optimum overall conversion and enantiomeric excess (56% with 60% ee), A-benzyl-V-methyl-... 

Acetaldehyde diethyl acetyl (acetyl) Cumene (isopropylbenzene) Cyclohexane Cyclopentene... 

Pudovik, A.N., and Gazizov, T.K., Thennal isomerization of diethyl acetyl phosphite and reactions of dialkyl acetyl phosphites with a-oxo phosphonic acid esters, Zh. Obshch. Khim., 38, 140, 1968 J. Gen. Chem. USSR (Engl. Transl.). 38. 139. 1968. 

Hellmann and Haas818 obtained a 94% yield of the 2,3-diaminopropionic acid on hydrolysis of the primary condensation product, itself obtained in 87% yield from A-[(dimethylamino)methyl]benzamide and diethyl (acetyl-amino)malonate. 

Certain 1,2,4-thiadiazoles undergo ring expansion on treatment with dialkyl acylphosphonates. Thus, the action of diethyl acetyl(or benzoyl)-phosphonates (383, R = Me, Ph) on 4-benzyl-3-methyl-l,2,4-thiadiazolium bromide (382) produces substituted 1,2,4-thiadiazines (384), albeit in low yield. The pyrimidyl analog (385, formally comparable with thiamin) behaves similarly, but a cyclization (to 387) competes with the ring expansion (to 386). The structure of these and other complex products, and the mechanism of their formation, were discussed in detail.286... 

It is also interesting that other mixed phosphorus(III) esters may react with a,j9-unsatu-rated aldehydes or methyl ketones in a similar fashion. Diethyl acetyl phosphite (but not... 

N-Acetyl-diethyl-L-aspartate. See Diethyl acetyl aspartate... 

Aspartic acid, N-acetyl-, diethyl ester. See Diethyl acetyl aspartate (+)-Aspartic acid 4-amide. See L-Asparagine L-Aspartic acid, N-(3-carboxy-1-oxo-2-sulfopropyl)-N-octadecyl-, tetrasodium salt L-Aspartic acid, N-(3-carboxy-1-oxosulfopropyl)-N-octadecyl-, tetrasodium salt. See Tetrasodium dicarboxyethyl stearyl sulfosuccinamate... 

Corn (Zea mays) gluten protein Creatinine Cupric sulfate anhydrous Cytochrome C Dandelion (Taraxacum officinale) extract Dandelion (Taraxacum officinale) root Diammonium lauryl sulfosuccinate Diethyl acetyl aspartate Diethyl aspartate Dihydrolanosterol... 

Diethyl acetyl aspartate C10H17N2O4PS Etrimfos C10H17N3O6S Glutathione C10H18... 

A mixture of 0.30 mol of the tertiairy acetylenic alcohol, 0.35 mol of acetyl chloride (freshly distilled) and 0.35 mol of /V/V-diethylaniline was gradually heated with manual swirling. At 40-50°C an exothermic reaction started and the temperature rose in a few minutes to 120°C. It was kept at that level by occasional cooling. After the exothermic reaction had subsided, the mixture was heated for an additional 10 min at 125-130°C, during which the mixture was swirled by hand so that the salt that had been deposited on the glass wall was redissolved. After cooling to below 50°C a mixture of 5 ml of 36% HCl and 200 ml of ice-water was added and the obtained solution was extracted with small portions of diethyl ether. The ethereal solutions were washed with water and subsequently dried over magnesium sulfate. The solvent was removed by evaporation in a water-pump vacuum... 

A -(2 2-Diethoxyethyl)anilines are potential precursors of 2,3-unsubstituted indoles. A fair yield of 1-methylindole was obtained by cyclization of N-inethyl-M-(2,2-diethoxyethyl)aniline with BFj, but the procedure failed for indole itself[2], Nordlander and co-workers alkylated anilines with bromo-acetaldehyde diethyl acetal and then converted the products to N-trifliioro-acetyl derivatives[3]. These could be cyclized to l-(trifluoroacetyl)indoles in a mixture of trifluoroacetic acid and trifluoroacetic anhydride. Sundberg and... 

The intense reddish-brown color of the acetylacetone titanium complexes impart a yellow discoloration to white inks. This discoloration is accentuated when the inks are used to print substrates that contain phenol-based antioxidants. The phenoHc compounds react with the organic titanate to form a highly colored titanium phenolate. Replacement of 0.25 to 0.75 moles of acetylacetone with a malonic acid dialkyl ester, such as diethyl malonate, gives a titanium complex that maintains the performance advantages of the acetyl acetone titanium complexes, but which is only slightly yellow in color (505). These complexes still form highly colored titanium phenolates. 

N-Acetyl-(R)-phanylalanlna (6). The rhodium catalyst was obtained by adding (-) dlop 5 (from diethyl tartrate) to a benzene solution of [RhCi(cyclooctene)2]2 under Ar, and stirring for tS mn A solution of the Rh catalyst (1 mM in EtOH PhH 4 1) was introduced under Hj to a solution of a-N acetylamino- phenytacrylic acid 4 (molar ratio Rh 4 1.540) The solvent was evaporated, the residue dissolved In 0 5 N NaOH, the catalyst was filtered and the solution acidified and concentrated to dryness to give 6 (81% ee) in 90 95% yield... 

Because phenols are weak acids, they can be freed from neutral impurities by dissolution in aqueous N sodium hydroxide and extraction with a solvent such as diethyl ether, or by steam distillation to remove the non-acidic material. The phenol is recovered by acidification of the aqueous phase with 2N sulfuric acid, and either extracted with ether or steam distilled. In the second case the phenol is extracted from the steam distillate after saturating it with sodium chloride (salting out). A solvent is necessary when large quantities of liquid phenols are purified. The phenol is fractionated by distillation under reduced pressure, preferably in an atmosphere of nitrogen to minimise oxidation. Solid phenols can be crystallised from toluene, petroleum ether or a mixture of these solvents, and can be sublimed under vacuum. Purification can also be effected by fractional crystallisation or zone refining. For further purification of phenols via their acetyl or benzoyl derivatives (vide supra). 

A-Acetyl-L-alaninamide [15962-47-7] M 130.2, m 162". Crystd repeatedly from EtOH-diethyl ether. 

A-Acetyl-L-alanyl-L-alanyl-L-alaninamide [29428-34-0] M 272.3, m 295-300 . Crystd from MeOH/diethyl ether. 

Acetylmethionine nitrile [538-14-7] M 172.3, m 44-46°- Crystd from diethyl ether. 5-Acetyl-2-methoxybenzaldehyde [531-99-7] M 166.2, m 144°. Crystd from EtOH or Et20. 

Initiation of polymerisation is said to be effected by zinc diethyl-water and aluminium trialkyl-water-acetyl acetone systems to give the structures indicated in Figure 19.12. 

Diethyl acetamidomalonate was first reported by Cherchez in 1931, when in an attempt to carry out a carbon alkylation of diethyl aminomalonate with acetyl chloride he obtained a quantitative yield of diethyl acetamidomalonate. This method of preparation, however, is not practical since diethyl aminomalonate is unstable and is made in relatively poor yields. 

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