Dielectrophoretic devices

Gupta, V., Jafferji, I., Garza, M., Melnikova, V., Hasegawa, D.K., Pethig, R., Davis, D.W., 2012. ApoStream , a new dielectrophoretic device for antibody independent isolation and recovery of viable cancer cells from blood. Biomicrofluidics 6, 024133. 

Recent advances in insulator dielectrophoretic devices have shown wide variety and creativity enabling highly functional electric field gradients. In all cases, highest field intensity occurs at sharp points or areas of highest curvature on the insulator as well as through areas of constriction in channels. 

A Comparison of Insulator-Based Dielectrophoretic Devices for the Monitoring and Separation of Water-Borne Pathogens as a Function of Microfabrication Technique, Chapter 9... 

The metrology data was used to create a numerical model for the dielectrophoretic devices. The calculated electric field profiles illustrate that non-tapered features are much more effective at creating local variations in field intensity than tapered features. The dynamics of each channel type were studied by the introduction of virtual tracers into the calculated electric field and a ratio of expected threshold voltages required to trap a particle in each channel type was calculated. While the model explained many of the experimentally... 

Li, H. B., and Bashir, R. (2002). Dielectrophoretic separation and manipulation of live and heat-treated cells of Listeria on microfabricated devices with interdigitated electrodes. Sens. Actuators B Chem. 86, 215-221. 

A continuous-flow dielectrophoretic spectrometer system has been developed based on insulating DEP teehniques with three-dimensional geometries on an insulating substrate [70]. Different field gradients were generated by fabricating devices in pol5miers with eonstrietions in the channel depth to create a deviee that eontinuously separates partieles with controls of transverse channel position. 

Fig. 5 Dielectrophoretic droplets sorting, (a) Schematic view of the device, (b) Schematic cross section of the device, (c) In the absence of an electric field, water droplets flow into the waste channel, (d) Applying an electric field, the droplets are attracted toward the energized electrode and flow into the collection channel. Reproduced with permission from [56]...

As a more complex example of integrated sample processing, Lagally et al. developed a device capable of dielectrophoretic cell sorting and on-chip cell lysis, followed by sequence-specific... 

An alternative to dielectrophoretic or magnetic force manipulation of microparticles in suspension is the use of acoustic standing wave forces, which also have served as the basis for particle and cell manipulation in microfluidic devices. Historical work by Kundt demonstrated early on the ability to move cork particles in a standing wave pattern. The fundamental acousto-physical principles have been well researched and described in the literature by King and Gorkov. ... 

AC Dielectrophoresis Lab-on-Chip Devices, Fig. 2 Dielectrophoretic manipulation techniques ... 

AC Dielectrophoresis Lab-on-Chip Devices, Fig. 5 An illustration of a dielectrophoretic microsystem that can selectively sort particles (top view). Recall that the electrodes are on the top and bottom surfaces of the microchannel and to not mechanically manipulate the particles... 

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