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2.6- Dichloro-3- pyrazine oxidation

Another exemplar of the power of multi-step library synthesis is the optimisation of a PDE2 inhibitor HTS hit (Scheme 18.36). The HTS hit itself was derived from a library that was synthesised to enrich the Pfizer screening collection. Key steps in the library synthesis involved reaction of the commercial dichloro pyrazine H with a range of alcohols, followed by reaction of the intermediate chloroalkyoxy pyrazine with hydrazine. Finally, the hydrazine pyridazine I was reacted with a number of aldehydes under oxidative conditions to form the triazolo pyrazine derivatives. This library allowed the project team to find key SAR directions for improvinbg selectivity vs. other PDEs. ... [Pg.515]

Pyrazine, 1,4-dialkyl-1,4-dihydro-isomerization, 3, 178 Pyrazine, dichloro-synthesis, 3, 187 Pyrazine, 2,3-dichloro-oxidation, 3, 169... [Pg.768]

Pyrazine, 2,5-dichloro-3,6-difluoro-synthesis, 3, 190-191 Pyrazine, dihydro-, 3, 177 Pyrazine, 1,2-dihydro-oxidation, 3, 178 reduction, 3, 177 Pyrazine, 1,4-dihydro-antiaromaticity, 3, 177-178 synthesis, 3, 177 Pyrazine, 2,3-dihydro-oxidation, 3, 178 Pyrazine, 2,5-dihydro-synthesis, 3, 178 Pyrazine, 3,6-dihydro-synthesis, 3, 184 Pyrazine, 2,5-dihydroxy-oxidation, 3, 175 Pyrazine, 2,3-dimethyl-1,4-dioxide... [Pg.768]

Oxidation with 2,3-dichloro-5,6-dicyano-l,4-benzoquinone (DDQ) converted ethyl l,2,3,4-tetrahydropyrido[2,3-A]-pyrazine-2-carboxylate 203 into the conjugated pyridopyrazine 205, while the 3-isomer 204 could not be oxidized to the corresponding aromatic heterocycle <2002T5241>. [Pg.782]

Heating with phosphoryl chloride converted 1 -hydroxy-3-phenyl-2( 1H )-pyrazinone (52) into the 2,5-dichloro derivative (53) via the 5-monochIoro species. It had been expected that chlorination would take place at C-6, but this occurred only to a minor extent. The observed chloride attack /3 to the oxygen function might be accounted for in terms of the sequence illustrated in Scheme 46 (86JHC149). Reaction mechanisms have been proposed to explain the observed a- and /3-chlorination when 2- and 3-substituted pyrazine Af-oxides are subjected to the Meisenheimer reaction. /3-Chlorination was rationalized in terms of electron withdrawal by the unoxidized nitrogen atom [84JCR(S)318] (Scheme 46). [Pg.316]

Trichloropyrazine may also be prepared by chlorination of 2,3-dichloro-pyrazine296 or, as previously mentioned, from triketopiperazine,273 296 but A-oxide rearrangement is probably the laboratory method of choice. A further application of A-oxide rearrangement for chloro-pyrazine preparation is taken from the work of Cragoe and his colleagues (Scheme 28).265... [Pg.159]

Forexample, good yields of 2-chloropyrazine 4-oxide,391,392 2-carbox-amidopyrazine 4-oxide,392 and 2-methylpyrazine 1,4-dioxide,391 have been obtained by oxidation of the appropriate pyrazine. In general, the preferred product from oxidation of monosubstituted pyrazines at lower temperatures is the monooxide formed by oxidation on the nitrogen remote from the substituent, whereas 1,4-dioxides are obtained by prolonged heating at higher temperatures.155 Pertrifluoro-acetic acid oxidation of 2,5-dichloro-3,6-dimethylpyrazine furnishes the di-iV-oxide, whereas permaleic acid gives only the mono-iV-oxide.393... [Pg.193]

Alkaline hydrolysis of the di-A-oxide of 2,5-dichloro-3,6-dimethyl-pyrazine (215) readily yields the monohydroxamic acid (216), but the second chlorine atom is inert. Both chlorine atoms in compound 215 may be displaced by ethoxide or benzyloxide ion. Acid treatment of the dibenzyloxy-1,4-dioxide (217) yields compound 218 which with... [Pg.200]

Chloro-3,6-diethylpyrazine (119, R = H) gave 2,5-diethyl-3-methylpyrazine (118) [Me3Al, Pd(PPh3)4, dioxane—C6H14, A, reflux, 2 h 88%] 280 2,5-dichloro-3,6-diethylpyrazine (119, R = Cl) gave 2,5-diethyl-3,6-dimethyl-pyrazine (120) (likewise but reflux, 4 h 93%) 280 and many homologues and their TV-oxides were made similarly.280,282... [Pg.97]

Pyrazin-l-oxid 3,6-Bis-[2-methyl-propyl]-2,5-dichloro- E9b/2, 307 (N-Oxidat.)... [Pg.1049]

A number of piperazine-2,5-diones (a-amino acid anhydrides ) has been converted to pyrazines by the action of phosphorus halides. Baxter and Spring (312) first described the conversion of isoleucine anhydride (45) with phosphoryl chloride to 2,5-di-s-butyl-3,6-dichloropyrazine (46, X = Cl) and 2,5-di-s-butyl-3-chloropyrazine (46, X = H), and of DL-alanine anhydride (47) similary to 2,5-dichloro-3,6-dimethylpyrazine (48, X = Q) and 3from alanine anhydride does not involve an oxidation step, whereas the formation of 2,5-dichloro-3,6-dimethylpyrazine involves the oxidation of an intermediate dihydropyrazine derivative. Treatment of DL-alanine anhydride with phosphoryl chloride in the presence of a tertiary base (dimethylaniline) gave only the monochloro derivative the intermediate dichlorodihydropyrazine presumably loses hydrogen chloride and gives the stable aromatic 3-chloro-2,5-dimethylpyrazine. [Pg.25]

Matsuura and co-workers (756) have reexamined the reactions of the A -oxides of 2,5-dimethylpyrazine and found that 2,5-dimethylpyrazine di-A -oxide (29) when heated with phosphoryl chloride at 160° gave 2,5-dichloro-3,6-dimethylpyrazine (6%) (30), 3-chloro-2,5-dimethylpyrazine 1-oxide (5%) (31), and 5-chloromethyl-2-methylpyrazine 1 -oxide (9%) (32). In addition small amounts of other chlorinated products, 3-chloro-2-chloromethyl-5-methylpyrazine (33) and 2,5-bischloromethyl-pyrazine (34), were identified. These authors also examined the action of p-tosyl chloride, methane sulfonyl chloride, and mixtures of phosphoryl chloride and concentrated sulfuric acid, but state that these did not give good results. Pyrazine 1-oxide and phosphoryl chloride have been shown to give 2reaction conditions it gave 2-chloropyrazine 1-oxide (757). Pyrazine 1,4-dioxide and benzenesulfonyl chloride also gave a low yield of 2-chloropyrazine 1-oxide (758). [Pg.89]

Dichloro-3,6-dimethylpyrazine 1,4-dioxide with phosphoryl chloride at 170° gave 2,5-dichloro-3,6-bis(chloromethyl)pyrazine and 2,5-dichloro-3-chloromethyl-6-methylpyrazine 1-oxide and 2,5-dichloro-3,6-dimethylpyrazine 1-oxide gave 2,5-dichloro-3-chloromethyl-6-methylpyrazine (756). [Pg.115]

Bredereck and Schmotzer (1044), from diaminomaleonitrile (DAMN hydrogen cyanide tetramer) and oxalyl chloride, prepared 2,3-dicyano-5,6-dihydroxy-pyrazine but Stetten and Fox (1049) could not prepare 23-diamino-5-hydroxy-pyrazine from glycine amide and oxamide. Section 11.3 lists preparations from a, -diamino or a, -diimino compounds and reagents other than a,0-dicarbonyl compounds (384) with additional data (1050) and oxidation of 23-dichloro-quinoxaline with hot aqueous potassium permanganate gave 23-dicarboxy-5,6-dihydroxypyrazine (1051). [Pg.157]

Some synthetic approaches to pyrazines relied on metal-assisted reactions. A synthesis of 6-substituted 5H-pyrrolol2,3-bJpyrazines via Pd-catalyzed heteroannulation from W-(3-chloropyrazin-2-yl)methanesulfonamide and alkynes was developed <04TL8087>, and 3- and 5-substituted 2(l//)-pyrazinones were prepared by Suzuki and Heck reactions using 3,5-dichloro-2(l//)-pyrazinones <04TL1885>. An improved synthesis of 6-substituted-5//-pyrrolo 2,3-iiJ-pyrazines via microwave-assisted Pd-catalyzed heteroannulation was developed <04TL8631>, and the reaction of a-diazo-P-keto esters with Boc amino acid amides in the presence of a Rh catalyst gave, after air oxidation, pyrazin-6-ones 111, which were then converted into tetrasubstituted pyrazines 112 <04OL4627>. [Pg.325]

In the synthesis of (III. 15) and (III.16) by Rosowsky and Chen [21], which was an application of the regioselective Taylor pteridine synthesis [22-24], 2-amino-5-chloromethyl-3-cyano-6-methylpyrazine A-oxide was condensed with diethyl A-[4-(A-methylamino)benzoyl]-L-glutamate, the A-oxide group was removed with triethyl phosphite in DMF at 125 °C, and the resultant pyrazine amino nitrile was condensed with gujmidine. Brief hydrolysis (15 min, 1 M NaOH in refluxing EtOH) led to (III. 15), and chlorination of (III.15) at 5 °C afforded the 3, 5 -dichloro derivative (III.16). Ultraviolet absorption spectra of (III. 15) and (III. 16) in 0.1 M NaOH were consistent with those reported in the literature for MTX and DCM, except for small... [Pg.16]

Piperazine Derivatives. Treatment of piperazine-2,5-diones with an excess of triethyloxonium fluoroborate gives 2,5-diethoxy-3,6-dihydropyrazines (390), which can be oxidized to the parent pyrazines (391) by dichloro-cyanobenzoquinone. c/s-Diben lpiperazin ione gives a mixture of cis- and /ra j-dihydropyrazines (390). Pyrolysis of the /ro s-isomer gives 3-benzyl-2,5-diethoxypyrazine (392) in high yield with the elimination of... [Pg.248]


See other pages where 2.6- Dichloro-3- pyrazine oxidation is mentioned: [Pg.158]    [Pg.305]    [Pg.286]    [Pg.305]    [Pg.243]    [Pg.177]    [Pg.305]    [Pg.488]    [Pg.488]    [Pg.770]    [Pg.770]    [Pg.101]    [Pg.113]    [Pg.152]    [Pg.153]    [Pg.177]    [Pg.279]    [Pg.269]    [Pg.221]    [Pg.214]    [Pg.750]   
See also in sourсe #XX -- [ Pg.212 ]

See also in sourсe #XX -- [ Pg.212 ]




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2- pyrazine oxidation

2.5- Dichloro-3- pyrazine

Pyrazine oxides

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