Dibucaine hydrochloride

FIG. 16 Chemical structures of (a) procaine hydrochloride, (b) lidocaine hydrochloride, (c) tetracaine hydrochloride, and (d) dibucaine hydrochloride. 

FIG. 1 Molecular structures of the drugs examined in the delivery study the general anesthetics, alkanols (I), halothane (II), enflurane (III), isoflurane (IV), halogenated cyclobutane (V) the local anesthetics, dibucaine hydrochloride (VI), procaine hydrochloride (VII), tetracaine hydrochloride (VIII), lidocaine hydrochloride (IX), benzyl alcohol (X) the endocrine disruptor, bisphenol A (XI), and alkylbenzenes, benzene (XII), toluene (XIII), ethylbenzene (XIV), and propylbenzene (XV). 

Hayashi K, Kawachi S, Saida T. Allergic contact dermatitis due to both chlorpheniramine maleate and dibucaine hydrochloride in an over-the-counter medicament. Contact Dermatitis 2001 44(l) 38-9. 

Nakada T, lijima M. Allergic contact dermatitis from dibucaine hydrochloride. Contact Dermatitis 2000 42(5) 283. 

Dibucaine Hydrochloride. 2-Butoxy-N-[2-(ditth-ylamino)ethyi]-4-quinolinecarbaxamide monohydrochloride 2-butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride benzol in Nupercaine Hydrochloride Percaine Cincaine Sovcaine Cinchocaine, CjjHjjCINjOj mol wt 379.92. C 63.22%, H 7.96%, Cl 9.33%, N 11,06%, O 8.42%. Prepn Miescher, L.S. pat. 1,825,623 (1931 to Ciba). Cam-... 

In an attempt to seareh for more potent and better tolerated local anaesthetics, it has been observed that the amides of quinoline derivatives are more potent than eommon local anaesthetics and the most important member in this elass is dibucaine hydrochloride. Besides, another member whieh essentially eontains an iso-quinoline nucleus but without an amide moiety, namely, dimethisoquine hydrochloride is reported to be one of the most potent loeal anaestheties. These two members will be deseribed below ... 

A. Dibucaine Hydrochloride USAN, Cinchocaine INN, Cinchocaine Hydrochloride BAN,... 

Dibromo-2,4-dicyanobutane Dibromopropamidine isethionate Dibucaine hydrochloride (Cinchocaine ) (ph) 7Z5(Dibutyldithiocarbamato) zinc... 

An 89-year-old man who had used over-the-counter topical antiseptics developed pruritic lesions over his left knee after using a topical medication containing benzalkonium chloride, dibucaine hydrochloride, chlorphenamine maleate, naphazoline hydrochloride, and a mixture of fragrance ingredients. There were pruritic erythematous papules and vesicles over the knee, and linear extensions down the lower leg appeared the next day. The dermatitis was successfully treated with topical glucocorticoids. Subsequent patch testing of the over-the-counter antiseptic was positive. 

The authors diagnosed allergic contact dermatitis to dibucaine hydrochloride, chlorphenamine maleate, and naphazoline hydrochloride, although none of these was patch tested in isolation. They speculated that sensitization to these three agents had occurred sequentially during previous exposures to the topical antiseptic. 

Yamadori Y, Oiso N, Hirao A, Kawara S, Kawada A. Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic. Contact Dermatitis 2009 61 52-3. 

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