Dibromopropamidine isethionate

Infra-red Spectrum. Principal peaks at wavenumbers 1190,1654, 1266, 1047, 1600, 1306 (dibromopropamidine isethionate, KBr disk). 

Russell AD, Furr JR. Comparitive sensitivity of smooth, rough and deep rough strains of Escherichia coli to chlorhexidine, quaternary ammonium compounds and dibromopropamidine isethionate. Int J Pharm 1987 36 191-197. 

Dibromo-2,4-dicyanobutane Dibromopropamidine isethionate Dibucaine hydrochloride (Cinchocaine ) (ph) 7Z5(Dibutyldithiocarbamato) zinc... 

Dibromopropamidine isethionate, C2xH3 jOioN4S2Br2, Mol. Wt. 722 5, is assayed in the B.P,C, by the Stepanow method given above using amyl alcohol as the solvent. 1 ml 0-lN AgNOg — 0-03612 g. 

The activity of diamidines is reduced by acid pH and in the presence of blood and serum. Microorganisms may acquire resistance by serial subculture in the presence of increasing doses of the compounds. Propamidine and dibromopropamidine, as the isethionate salts, are the major diamidine derivatives employed as antimicrobial agents propamidine in the form of eye-drops (0.1%) for amoebic infection and dibromopropamidine for topical treatment of minor infections. 

Dibromopropamidine diisethionate (Dibromopro-pamidine isethionate, Brolene ointment, Brulidine, CAS no. 614-87-9) (Liitzow-Holm and Ronnevig 1988). Patch-test concentrations are 1-5% pet. 

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