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Dibucaine

They decrease the CICR activity without changing the Ca2+ sensitivity. Tetracaine is more potent than procaine. It should be noted that some local anaesthetics, e.g. dibucaine may stimulate CICR. [Pg.1099]

Lidocaine (112), xyloceiine, and dibucaine (113) have been formulated in homo- and copolymers of lactide and glycolide. The goal of these studies has been relatively short-term (24-hr) controlled release of the anesthetic. Injectable microcapsules of lidocaine hydrochloride were produced by an air suspension coating technique and administered i.m. to rabbits (112). Serum levels of Udocaine indicated an initial rise over the first 2 hr and then a gradual decline with clearance after about 8-10 hr. [Pg.24]

Wakiyama, N., Juni, K., and Nakano, M., Preparation and evaluation in vitro and in vivo of polylactic acid microspheres containing dibucaine, Chem. Pharm. Bull., 30, 3719, 1982. [Pg.39]

Local anesthetics interact with peripheral nerve cell membranes and exert a pharmacological effect [34]. Potential oscillation was measured in the presence of 20 mM hydrochlorides of procaine, lidocaine, tetracaine, and dibucaine (structures shown in Fig. 16) [19]. Amplitude and the oscillatory and induction periods changed, the extent depending on the... [Pg.712]

FIG. 16 Chemical structures of (a) procaine hydrochloride, (b) lidocaine hydrochloride, (c) tetracaine hydrochloride, and (d) dibucaine hydrochloride. [Pg.713]

Local anesthetics Dibucaine Procaine Tetracaine Lidocaine Benzyl alcohol... [Pg.772]

FIG. 1 Molecular structures of the drugs examined in the delivery study the general anesthetics, alkanols (I), halothane (II), enflurane (III), isoflurane (IV), halogenated cyclobutane (V) the local anesthetics, dibucaine hydrochloride (VI), procaine hydrochloride (VII), tetracaine hydrochloride (VIII), lidocaine hydrochloride (IX), benzyl alcohol (X) the endocrine disruptor, bisphenol A (XI), and alkylbenzenes, benzene (XII), toluene (XIII), ethylbenzene (XIV), and propylbenzene (XV). [Pg.773]

Local anesthetics are positively charged amphiphiles in solution. We have selected hydrochlorides of dibucaine (DBC H ), procaine (PRC H ), tetracaine (TTC H ), and lido-caine (LDC H ). All of these drugs are structurally similar they consist of the substituted benzene ring and tertiary amine moieties, as shown by (VI)-(IX) in Fig. 1. The presence of the positive charge increases the solubility in water and in consequence, the anesthetic efficiency. [Pg.788]

DL-polylactic acid 25-75 Subcutaneous delivery of local anesthetics Dibucaine tetracaine... [Pg.551]

Seelig, A., Local anesthetics and pressure a comparison of dibucaine binding to lipid monolayers and bilayers, Biochim. Biophys. Acta 1987, 899, 196-204. [Pg.491]

Eftink, M. R., Puri, R. K. and Ghahramani, M. D. (1985). Local anesthetic-phospholipid interactions. The pH-dependence of the binding of dibucaine to dimyristoylphosphatidylcholine vesicles, Biochim. Biophys. Acta, 813, 137-140. [Pg.265]

Deserpldine, 320, 321 Desimlpramine, 402 Desmethylmorphine, 289 Desulfurization, 130, 166 Dexamethosone, 199 Dexbrompheniramine, 77 Dexchlorpheniramine, 77 Dextroamphetamine, 70 Dextromoramide, 82 Dextromorphan, 293 Dextrothyroxine, 92 Diabetes, 136 Dianlthazole, 327 Diazepam, 365, 366 Diazoxide, 355 Dibenamine, 55 Dibenzepine, 405 Dibucaine, 15 Dicarbocyanine dye, 327 Dichlorisone, 203 Dichloroisoproteronol, 65, 66 Dichlorophenamide, 133 Dicloxacillin, 413 Dicoumarol, 147 Dicyclonine, 36... [Pg.480]

Dibucaine (Nupercainal) Doxepin, Topical (Zonalon, Prudoxin) Econazole (Spectazole) Efalizumab (Raptiva) Erythromycin, Topical (A/T/S, Eryderm, Erycette, T-Stat) Erythromycin Benzoyl Peroxide (Benzamycin) Finasteride (Propecia) Fluorouracil, Topical [5-FU] (Efudex) Gentamicin, Topical (Garamycin, G-Mycitin)... [Pg.44]

Alosetron (Lotronex) Budoneside, oral (Entocort EC) Balsalazide (Colazal) Dexpanthenol (Ilopan-Choline Oral, Ilopan) Dibucaine (NupCTcainal) Dicyclomine (Bentyl) Hydrocortisone, Rectal (Anusol-HC Suppository, Cortifoam Rectal, Proctocort, oth s) Hyoscyamine (Anaspaz, Cystospaz, Levsin, othCTs)... [Pg.49]

Dibucaine (Nupercainal) Lidocaine Prilocaine (EMLA, LMX) Lidocaine/Tetracaine Transdermal (Synera)... [Pg.54]

Dibucaine (Nupercainal) [Topical Anesthetic] U e Hemor-rhoids minor skin conditions Action Topical anesthetic Dose Insert PR w/ applicator bid aftCT each bowel movement apply sparingly to skin Caution [C, ] Contra Component sensitivity Disp Oint w/ rectal applicator 0.5% cream SE Local irritation, rash Interactions None noted EMS Can cause allergic Rxn in those w/ sulfite aU gy OD May cause blurred vision, tinnitus, bradycardia, tremors s5rmptomatic and supportive... [Pg.132]

Amide linked local anaesthetics e.g. lidocaine, bupivacaine, dibucaine, prilocaine, ropivacaine. [Pg.115]

See other pages where Dibucaine is mentioned: [Pg.603]    [Pg.15]    [Pg.442]    [Pg.266]    [Pg.236]    [Pg.358]    [Pg.608]    [Pg.473]    [Pg.191]    [Pg.192]    [Pg.192]    [Pg.90]    [Pg.91]    [Pg.689]    [Pg.713]    [Pg.781]    [Pg.195]    [Pg.1055]    [Pg.109]    [Pg.1308]    [Pg.34]    [Pg.461]    [Pg.132]    [Pg.342]    [Pg.115]    [Pg.115]   
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Dibucaine base

Dibucaine cholinesterase inhibition

Dibucaine hydrochloride

Dibucaine hydrochloride - Cinchocaine

Dibucaine membranes

Dibucaine number

Dibucaine resistant pseudocholinesterase

Dibucaine toxicity

Dibucaine-resistant variant

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