Diazonium salts, reduction

Pandurangappa, M., and Ramakrishnappa, T. 2008. Derivatization and characterization of functionalized carbon powder via diazonium salt reduction. Journal of Solid State Electrochemistry 12, 1411-1419. 

Figure 9.2 Functionalization of conductive surfaces by an amino-polyphenylene layer via diazonium salt reduction [27].

FIG. 15. Diazonium salt reduction on a boron-doped nanocrystaUine diamond thin-film electrode (A) general reaction mechanism, (B) a series of cyclic vol-tammetric i-E curves in 1 mM 4-nitrophenyldiazonium salt + 0.1 M TBABF4/ CH3CN during the surface derivatization step, and (C) a cyclic voltammetric i-E curve for the derivatized surface in 0.1 M TBABF4/CH3CN. Scan rate = 0.05 V/s. Electrode area = 0.2 cm. ... 

Azo-compounds can be obtained by reduction of nitro-compounds, or by oxidation of hydrazo-compounds. They are usually prepared, however, by reacting a phenol or amine with a diazonium salt. The coupling usually takes place in the position para to the hydroxyl or amino group, but if this position is occupied it goes to the ortho position, e.g. 

The most noteworthy reaction of azo-compounds is their behaviour on reduction. Prolonged reduction first saturates the azo group, giving the hydrazo derivative (C NH-NH C), and then breaks the NH NH linkage, with the formation of two primary amine molecules. If method (1) has been employed to prepare the azo-compound, these two primary amines will therefore be respectively (a) the original amine from which the diazonium salt was prepared, and (6) the amino derivative of the amine or phenol with which the diazonium salt was coupled. For example, amino-azobenzene on complete reduction gives one equivalent of aniline, and one of p-phenylene diamine, NHaCeH NH benzene-azo-2-naphthoI similarly gives one equivalent of aniline and one of... 

The preparation of 5-azothiazoles uses the nucleophilic character of C-5 carbon in reaction with the appropriate diazonium salt (402, 586). These 5-azothia2oles form 1 1 complexes with Ag (587). 2-Amino-4-methyl-5-arylazothiazoles give reduction waves involving two-electron transfer the Ej/ values correlate to the angle between the thiazole and phenyl rings (588). 

Sodium borohydride has also been used to reduce aryl diazonium salts m reductive deam mation reactions... 

Reductive deamination of primary arylamines The ammo substituent of an arylamine can be replaced by hydrogen by treatment of its de rived diazonium salt with ethanol or with hypophosphorous acid... 

Aromatic Hydrazines. A general synthesis for aryUiydraziaes is via diazotization of aromatic amines, followed by reduction of the resulting diazonium salt (18) ... 

The most important synthesis of pyrazolones involves the condensation of a hydrazine with a P-ketoester such as ethyl acetoacetate. Commercially important pyrazolones carry an aryl substituent at the 1-position, mainly because the hydrazine precursors are prepared from readily available and comparatively inexpensive diazonium salts by reduction. In the first step of the synthesis the hydrazine is condensed with the P-ketoester to give a hydrazone heating with sodium carbonate then effects cyclization to the pyrazolone. In practice the condensation and cyclization reactions are usually done in one pot without isolating the hydrazone intermediate. 

SnCl2 reduction produced the 4-hydrazinoisoxazole (243). In ethanol the diazonium salt reacted with the 4-aminoisoxazole to produce the linear triazine (244) (Scheme 85). Diazoisoxazoles can also be treated with KI or H20/urea to produce the 4-iodo or 4-hydroxy derivatives (63AHC(2)365). These Sandmeyer reactions have been extended to a variety of isoxazole systems (77JMC934, 63AHC(2)365). 

Other limitations of the reaction are related to the regioselectivity of the aryl radical addition to double bond, which is mainly determined by steric and radical delocalization effects. Thus, methyl vinyl ketone gives the best results, and lower yields are observed when bulky substituents are present in the e-position of the alkene. However, the method represents complete positional selectivity because only the g-adduct radicals give reductive arylation products whereas the a-adduct radicals add to diazonium salts, because of the different nucleophilic character of the alkyl radical adduct. ... 

The second point is somewhat less obvious but is readily illustrated by the synthesis of 1,3,5-tribromobenzene. This particular- substitution pattern cannot be obtained by direct brornination of benzene because bromine is an ortho, para director. Instead, advantage is taken of the powerful activating and ortho, para-directing effects of the fflnino group in aniline. Brornination of aniline yields 2,4,6-tribromoaniline in quantitative yield. Diazotization of the resulting 2,4,6-tribromoaniline and reduction of the diazonium salt gives the desired 1,3,5-tribromobenzene. 

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