Diazepam hormonal

Stuer et al. [46] evaluated the presence of the 25 most used pharmaceuticals in the primary health sector in Denmark (e.g., paracetamol, acetyl salicylic acid, diazepam, and ibuprofen). They compared PECs with experimental determinations and they conclude that measured concentrations were in general within a factor of 2-5 of PECs. Carballa et al. [45] also determined PECs for pharmaceuticals (17), musk fragrances (2) and hormones (2) in sewage sludge matrix. For that purpose they used three different approaches (1) extrapolation of the per capita use in Europe to the number of Spanish inhabitants for musk fragrances (2) annual prescription items multiplied by the average daily dose for pharmaceuticals and (3) excretion rates of different groups of population for hormones. They indicated that these PECs fitted with the measured values for half of them (carbamazepine, diazepam, ibuprofen, naproxen, diclofenac, sulfamethoxazole, roxithromycin, erythromycin, and 17a-ethiny I e strad iol). 

Nako Y, Tachibana A, Harigaya A, Tomomasa T, Morikawa A. Syndrome of inappropriate secretion of antidiuretic hormone complicating neonatal diazepam withdrawal. Acta Paediatr 2000 89(4) 488-9. 

Antianxiety agents e.g., chlordiazepoxide, diazepam Diuretics e.g., hydrochlorothiazide Hormone therapies Oral contraceptives, hormone replacement therapy... 

Many compounds isolated from natural sources are aromatic in part. In addition to benzene, benzaldehyde, and toluene, such compounds as the steroidal hormone estrone and the well-known analgesic morphine have aromatic rings. Many synthetic drugs are also aromatic in part the tranquilizer diazepam (Valium) is an example. 

Koulu M, Lammintausta R, Kangas L, Dahlstrom S. The effect of methysergide, pimozide and sodium valproate on the diazepam-stimulated growth hormone secretion in man. J Clin Endocrinol Metab 1979 48 119-22. 

Laakmann, G., Treusch, 1., Eichmeier, A., Schmauss, M., Treusch, U., and Wahlster, U. 1982. Inhibitory effect of phenotolamine on diazepam-induced growth hormone secretion and lack of effect of diazepam on prolactin secretion in man. Psychoneuroendocrinology 7 135-39. 

Tomicheck RC, Rosow CE, Philbin DM, Moss J, Teplick RS, Schneider RC. Diazepam-fen-tanyl interaction — hemodynamic and hormonal effects in coronary artery surgery. Arresth Analg ( 9S3) 62, 881-4. 

Hormonal contraceptives can increasie the effects of alprazolam, chlordiazepoxide, diazepam, nitrazepam and triazolam, and reduce the effects of oxazepam, lorazepam and temazepam, but whether in practice there is a need for dos age adjustments has not been determined. Chlordiazepoxide, diazepam, nitrazepam and meprobamate can possibly increase the incidence of breakthrough bleeding. 

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