1.3- Diaminopropane, reaction with

By judicious choice of reaction conditions an acyclic Ni11 complex (784) could be isolated, which serves as a valuable starting material for the preparation of unsymmetrical and mixed metal complexes by subsequent reaction with various amines. Also, a symmetrical Schiff base macrocycle of larger size has been obtained as a minor byproduct upon condensation of (784) with 1,3-diaminopropane. The resulting Ni11 complex (785) is again bimetallic, although room to bind four metal ions is in principle available.1367... 

The conversion of 2,4-bis(4-cyanophenyl)-6-dimethylamino-13,5-triazine into the corresponding diaryl cyclic diamidine via reaction with an excess of 1,2-diaminopropane saturated with hydrogen sulfide has been reported. 2,4-Bis(4-cyanophenyl)-133-triazine is resistant to cyclization in reacting with 1,4-diaminobutane under similar conditions and affords 2,4-bis[4-[V-(4-aminobutyl)thiocarbamoyl]phenyl]-133-triazine <99TL2841>. 

The monohydrazones of a-diketones react with acetone and nickel(II) acetate to give azine complexes (82), which can be converted to macrocyclic complexes by reaction with 1,2-diamino-ethane, but not 1,3-diaminopropane (Scheme 34).179-181... 

The first step follows a modification of the well known procedure of Krej-carek and Tucker [38] yielding the monomethylamide of DTPA 27. After dehydration with glacial acetic acid the monomethylimide 28 has been obtained as an activated polycarboxylate compound. Subsequent reaction with 1,3-diaminopropane yielded the DTPA-mono(methyl-propylamino)amide Hydro-choride 29. The reaction of 29 with 28 afforded the dimeric ligand 30. 

Cyclic ketene acetals can also react with amines to give 1,1-enediamines with elimination of ethylene glycol76. Treatment of 2-[(methoxycarbonyl)cyanomethylene]-1,3-dioxolane (38) with 1,3-diaminopropane or with 4,5-dimethyl-1,2-phenylenediamine gives the hexahydropyrimidine and the benzimidazoline derivatives 39 and 40, respectively (equation 11). Similarly to the reaction of ketene dithioacetals with amines, the reaction between ketene acetals and amines proceeds via monoamino-substituted intermediates and ketene 7V,Oacetals can be isolated when one molar amine is used72. 

Ten-membered. V,.V, ., -tris(tosyl)-l,4,7-triazacyclodecane 31 was obtained by Richman-Atkins reactions of fully tosylated iV,iV -bis(ethanol-2-yl)-l,3-diaminopropane with tosylamide in nearly quantitative yield (Scheme 1) <2001EJ04233>. Interestingly, reaction with benzylamine afforded the analogous macrocyclic product 32 in much lower yield (25%) <2001EJ04233>. Similar 10-membered triazamacrocycle 33 was obtained by the cyclization with propyleneglycol bis(triflate) in 33% yield (Scheme 1) <1999TL7687>. 

An entirely different result is observed with Pic and 93d. Reaction of 93c with base (LDA, THF, —75 °C, 1 h t-BuOK, DMSO, 25 °C, 5 h) led to complete recovery of starting material. Pit/is also unreactive towards base (t-BuOK, DMSO, 70 °C, 6 h KAPA, 1,3-diaminopropane, 25 °C, 24 h). Thus, the impossibility of preparing a cyclopropyl anion of the type 94 from Pic and the extremely low acidity of 93d prevent a reaction with base although electron transfer from base to initiate pathway B (Scheme 6) could still occur. 

DIAMINOPROPANE (78-90-0) Forms explosive mixture with air (flash point 75°F/ 24°C). Violent reaction with oxidizers, strong acids. A strong organic base. Incompatible with organic anhydrides, alkylene oxides, epichlorohydrin, aldehydes, alcohols, glycols, phenols, cresols, caprolactam solution. Contact with mercury forms shock- and friction-sensitive explosive compounds. Attacks red metals and their alloys. 

So far we have seen the reactions of chlorocyclophosphazenes with reagents that may be termed monofunctional. For example, a phenol in its reactions with chlorocyclophosphazenes will react as a nucleophile and form N3P3(OPh)6 containing P-0 linkages. If instead of a phenol we used a biphenol we will have two sites that can react with the phosphorus centers. In this manner there are several difunctional reagents such as diamines (ethylenediamine, 1,3-diaminopropane, phenylenediamine), diols (ethyleneglycol, 1,3-propanediol, catechol), and amino alcohols (ethanolamine, propanolamine, o-aminophenol) [2,15]. 

Sterols are separated as 3,5-dinitrobenzoic acid derivatives by thin layer chromatography and, after reaction with 1,3-diaminopropane, are determined quantitatively with high sensitivity in the form of a Meisenheimer adduct. Sterols and triterpene alcohols are silylated and then analysed by gas chromatography. One application of this method is illustrated by the detection of 5% coberine in cocoa butter (Fig. 3.44). The compounds a-amyrine and lup-20(29)-en-3P-ol (Formula 3.113a and 3.116) serve as indicators. They are present in much higher concentrations in some cocoa butter substitutes than in cocoa butter. Coberine is a cocoa butter substitute made by blending palm oil and shea butter (the shea is an African tree with seeds that yield a thick white fat, shea butter). 

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