1.3- Diamino-2,2-dimethyl

In this strategy, the Bucherer-Bergs reaction was crucial for the synthesis of two bis-spirohydantoins with trans-geometry represented in Scheme 10.14 in excellent yields. The resulting diamino dimethyl carboxylate 57 is following converted in the desired trawi-linker 56. 

DiaminO 4,4-dimethyl-l,3,5-thiadiazine hydrobromide was isolated as by-product (418). Benzene sulfonates of cyanohydrin prepared from sodium cyanide and an halobenzoaldehyde, when treated with thiourea or its derivatives, afford 2,4-diamino-5-(p-halogenophenyl)-thiazole benzene sulfonates (447). Similarly, cyanoamido thiocarbamates obtained from cyanamide and isothiocyanates yield substituted 2,4-diaminothiazoles (598). 

Imidazole, 2-deutero-l, 4-dimethyl-photolysis, 5, 377 Imidazole, 2,4-dialkyl-benzylation, 5, 388 Imidazole, 4,5-dialkyl-synthesis, 5, 481, 482 Imidazole, 1-dialkylphosphoryl-decomposition, 5, 455 Imidazole, 1,2-diamino-reactions... 

Pteridine, 2,4-diamino-6,7-diisopropyl-pharmacological properties, 3, 325 Pteridine, 2,4-diamino-6,7-dimethyl-pharmacological properties, 3, 325 Pteridine, 2,4-diamino-2,6-diphenyl-... 

Selenophene, 2,5-diamino-3,4-dicyano-synthesis, 4, 119, 964 Selenophene, 2,4-diaryl-synthesis, 4, 967 UV spectra, 4, 941 Selenophene, 2,5-diaryl-synthesis, 4, 967, 969 UV spectra, 4, 941 Selenophene, 2,5-dichloro-metallation, 4, 949 Selenophene, dihydro-3-methylene-synthesis, 4, 963 Selenophene, 2,5-dimethoxy-lithiation, 4, 949 Selenophene, 2,4-dimethyl-... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

Scott et al. [45] prepared diimine derivatives of 2,2 -diamino-6,6 -dimethyl-biphenyl (as structure 37 in Scheme 19) as copper chelates for the catalyzed cyclopropanation reaction. All catalysts were active in this reaction but enan-tioselectivities varied importantly according to the substitution pattern of the imine aryl group only ortho-substituted ligands (by chloride or methyl groups) led to products with measurable enantioselectivity for the model test reaction (up to 57% ee with 37). 

Synthetic Method 7 l,9-dimethyl-4-acetarnido-8-diethylaminoimidazo-phenoxazine (31) (procedure from U.S. Patent 4,604,462). 12 A mixture of 10 g of l,3-diamino-7-diethylamino-8-methylphenoxazin-5-ium chloride (Brilliant Cresyl Blue), 50 ml of acetic anhydride, 10 g of zinc dust, and 10 ml of pyridine was maintained at 85 to 90°C for approximately 1 h. After cooling to room temperature, the reaction mixture was poured into a mixture of water and toluene and the resulting aqueous layer was discarded. The toluene solution was washed twice, first with water and then with... 

A range of bis- and tris-spirocyclic cyclotriphosphazenes 182-187 containing bi-2-napthoxy, 2,2 -biphenoxy, 2,2-dimethyl-1,3-propane diamino, and 2,2-dimethyl-1,3-propane dioxy ligands have been prepared from the appropriate diamines and diols <2004POL979>. 

Scheme 6.266 Synthesis of 4,6-diamino-2,2-dimethyl-l,2-dihydro-l-phenyl-l, 3,5-triazines.

Treating glycosyl isothiocyanates 415 with 5,6-diamino-1,3-dimethyl-uracil (416) gave thioureas 417, which on oxidative cyclization with N-bromosuccinimide afforded 5,7-dioxopyrimido[5,4- ][1,2,4]triazine nucleosides 418 (80MI1 82MI2). 

A different approach is the combination of a Pt-carbonyl-cluster with a special dye, Safranine O (Saf 3,7-diamino-2,8-dimethyl-5-phenylphenazinium) in an aqueous/organic two-phase system [48]. The dye is reduced in the organic phase and subsequently, in a type of phase-transfer catalysis, it reduced the cofactor in the aqueous phase. In this example l-LDH is used as a production enzyme, reducing pyruvate to L-lactate (Scheme 43.6). Complete conversion was obtained within 48 h, the mixture containing pyruvate, NAD+ and the Pt-cluster catalyst in a 600 10 1 molar ratio. The TOF for NAD+ was 15 h-1. 

The macrocyclic ligand 6,13-diamino-6,13-dimethyl-1,4,8,11 -tetra-azacyclotetradecane (diammac), illustrated in Scheme 5 for the two cis and trans conformations, is properly suited to fulfil the requirement of six donor atoms to satisfy the Cr(III) hexacoordination. In fact, in addition to the four central N atoms it has two amine groups (a sort of head and tail, from which the name scorpiands is given to these ligands). 

A related hexacoordinate macrocycle complex is the Fe(III) derivative with the scorpiand 6,13-diamino-6,13-dimethyl-1,4,8,11-tetraazacyclo-tetradecane (the traws-diammac ligand already discussed in Section 2), [Fe(tra s-diammac)]3 +. Its octahedral geometry is shown in Figure 67.103... 

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