4.7- Diamino-5,6-dimethyl-1-ethyl

Pyridine, 3-amino, 30, 3 5-ETHYL-2-METHYL, 30, 41 4-Pyrimidol, 2,6-diamino-, 32, 45 Pyrogallol-1,3-dimethyl ether, 31, 92 Pyrolysis, of, V-a.zo-bis- -cyclohexane-nitrile to l,l -dicyano-l,l -bicyclo-hexyl, 32, 48... 

The A -l-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde 22, R = Me) and A -l-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl (22, R = iBu) derivatives of diamino acids are stable towards trifluoroacetic acid, piperidine/DMF (20% piperidine in NMP for 117 min cleaves the Dde group to an extent of only 2.1% ) and DBU, but are easily cleaved with 2% hydrazine in DMF. The preferential protection of primary versus secondary amines is explained by the formation of hydrogen bonds in the product. Further deriv-... 

Diamino-3-carboxy-5-chloropyrazine in dimethyl sulfoxide (a) with N,N dicyclohexylcarbodiimide gave 2,6-diamino-3-chloro-5-(2, 5 -dioxopyrrolidin-l ylcarbonyOpyrazine ( ) (962), (6) with dicyclohexylcarbodiimide (and 2-hydrazino pyrimidine) gave 2,6-diamino-3-chloro-5-(A -cyclohexyl-V-cyclohexylcarbamoyl) carbamoylpyrazine (1331), and (c) as its triethylamine salt with V-ethyl-5-phenyl... 

The other members of this family of compounds are phosphorodithioic acid derivatives. Of these, menazon, 0,0-dimethyl-S-(4,6-diamino-l,3,5-triazin-2-yl)-methyl phosphorodithioate (78), distinguishes itself by its low toxicity to warmblooded animals. It is prepared by cyclisation of biguanide and ethyl chloroacetate, upon which the 2-chloromethyl-4,6 iaminotriazine formed is reacted with sodium 0,0-dimethyl phosphorodithioate (Anonym, 1958). 

Die Reaktion wird hauptsachlich mit Oxiran, Methyl-oxiran, seltener mit 2,3-Dimethyl-bzw. Ethyl-oxiran durchgefiihrt und kann sowohl als Druckreaktion als auch unter Nor-maldruck ablaufcn. So erhalt man z. B. im Autoklaven unter 0,6-10 bar Oberdruck mit 3% Dimethyl-dodecyl-amin ( ) bzw. 3% 1,6-Diamino-hexan ( ) als Base folgende Ester ... 

Acylation of 3,5-diamino-1,2,4-thiadiazole by ethyl chloroformate yields the 3,5-bis(ethoxycarbonylamino) derivative.67 Phosphorochloridic esters [(RO)2POCl] attack the 3-position preferentially, producing the phosphor-amidic esters (509).390 The action of diphenylphosphinothioic chloride (Ph2PSCl) (see Section IV,C) on Hector s base in pyridine yields a monoacyl derivative, substitution occurring probably at the exocyclic imino group.391 Methylation of 3,5-bisanilino-l,2,4-thiadiazole with sodium hydride-methyl iodide in dimethylformamide produces the mono and dimethyl derivatives, of structures 510 and 511, as shown by 15N and 13C NMR spectroscopy.31... 

A variant of the previous reaction was utilized for the synthesis of the l,3-dimethyl-8(/3-D-ribofuranosyl)xanthosine 515 the ethyl 2,5-anhydro-o-allonodithioate derivative 512 was cyclocondensed with 5,6-diamino-l,3-dimethyluracil (513) followed by removal of the 0-protective group of 514 (86MI4) (Scheme 138). 

The influence of steric, inductive, and ring-strain effects on the complexation of Cu(II) by four new tetradentate diamino diamide ligands (4-methyl-4,7-diazadecandediamide, 4-Me-L-2,2,2 4,7-dimethyl-4,7-diazadecanediamide, 4,7-Me2-L-2,2,2 4-ethyl-4,7-diazadecanediamide, 4-Et-L-2,2,2 and 4-methyl-4,8-diazaundecanediamide, 4-Me-L-2,3,2) has been investigated in a spec-trophotometric SF study/ For the complexation and decomplexation reactions, respectively, Eqs. (22) and (23) hold, where and fccH refer to complexation by... 

---