Diagnostic clinical chemistry

Jayasena, S.D. (1999) Aptamers an emerging class of molecules that rival antibodies in diagnostics. Clinical Chemistry, 45, 1628 1650. 

It is estimated that the worldwide clinical chemistry diagnostics market is about 3 biUion. This amount includes an estimated 700 million in instmment sales, and 2.3 bUHon in sales of reagents and consumables. Some of the principal instmment manufacturers are Hitachi (Japan), Miles Laboratories/Technicon Instmments (United States), E. I. du Pont de Nemours (United States), Beckman Instmments (United States), Eastman Kodak (United States), Abbott Laboratories (United States), Olympus (Japan), Toshiba (Japan), Hoffmann-La Roche (Switzerland), and Ciba Corning Diagnostics (United States). 

Sch artZ9 M.K. "Interferences In Diagnostic Biochemical Procedures". Advances In Clinical Chemistry> pp. 1-45,... 

The direct and immediate use of laboratory data in medical diagnostic decision making is unique, so the proper use of reference materials in conjunction proficiency testing clinical chemistry is vital if false and mis diagnosis is to be avoided. 

DANIEL S. DANIEL Clinical Chemistry Research and Development, Johnson Johnson Clinical Diagnostics, Rochester, New York 14650-2113. 

In clinical chemistry and medical diagnostics the true positive rate is called sensitivity rate and the true negative rate specificity rate (O Rangers and Condon [2000]) without any relation to the general definition of the terms sensitivity and specificity and their use in analytical chemistry (see Sects. 7.2 and 7.3). 

Doctor s office and/or bedside clinical chemistry and diagnostics... 

TECO, Clinical Chemistry Reagents—Uric acid, TECO Diagnostics, Anaheim, CA, USA (http //www.tecodiag.com/Portal/DesktopDefault.aspx tabindex=0 tabid=37). 

Rinaldo P, Hahn SH, Matern D (2005) Inborn errors of amino acid, organic acid, and fatty acid metabolism. In Burtis CA, Ashwood ER, Bruns DE (eds) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th edn. Saunders, St. Louis, Missouri, pp 2207-2247... 

This volume marks the first issue of a biannual publication for the Advances in Clinical Chemistry series. Starting this year, the series will be published twice a year to keep the readership abreast of the rapid changes and latest developments in clinical chemistry, clinical laboratory science, and laboratory diagnostics. 

With the introduction of quality assurance in the diagnostic laboratory 56 years ago [6], a kind of educational and benchmarking process started forcing laboratories, national and international organizations, and the IVD industry to improve the methods applied in clinical laboratories. Comparison of the measurements of enzyme activity demonstrate that the analytical performance of the methods applied 30 years ago were far beyond the biological variation and most probably insufficient for medical needs. Interlaboratory comparisons show that with the new routine methods based on recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) (Table 5) comparable results can be obtained irrespective of time and space and thus small individual variations can now be detected. Similar improvements in the analytical process in clinical laboratories can be reported generally for homogenous measurands. 

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