Diabetes mellitus hyperglycemia control

Those with type 1 diabetes mellitus produce insulin in insufficient amounts and tiierefore must have insulin supplementation to survive Type 1 diabetes usually has a rapid onset, occurs before die age of 20 years, produces more severe symptoms tiian type 2 diabetes, and is more difficult to control. Major symptoms of type 1 diabetes include hyperglycemia, polydipsia (increased thirst), polyphagia (increased appetite), polyuria (increased urination), and weight loss. Treatment of type 1 diabetes is particularly difficult to control because of the lack of insulin production by die pancreas. Treatment requires a strict regimen tiiat typically includes a carefully calculated diet, planned physical activity, home glucose testing several times a day, and multiple daily insulin injections. 

Insulin glargine is given SC once daily at bedtime This type of insulin is used in the treatment of adults and children with type 1 diabetes mellitus and in adults widi type 2 diabetes who need long-acting insulin for die control of hyperglycemia. 

Type 2 diabetes mellitus As an adjunct to diet and exercise to lower the blood glucose in patients with type 2 diabetes mellitus and in combination with metformin or thiazolidinediones to lower blood glucose in patients whose hyperglycemia cannot be controlled by exercise, diet, and either agent alone. 

Insulin detemir Treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia. 

The drug metformin is useful in the treatment of patients with type 2 diabetes mellitus who are obese and whose hyperglycemia cannot be controlled by other agents. There are reports that some patients are predisposed to the toxic side effects of this drug, which include potentially fatal lactic acidosis. 

B. Indications and use Humalog is an insulin analogue that is indicated in the treatment of patients with diabetes mellitus for the control of hyperglycemia. It has a more rapid onset and shorter duration of action than human regular insulin. 

Indications Treatment of adult patients with diabetes mellitus, for the control of hyperglycemia... 

Treatment of patients with diabetes mellitus tor the control of hyperglycemia GI 124617 insulin precursor PID gl24617 Lys(B28)Pro(B29)-human insulin PDB ID ILPH... 

First-line therapy for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (Type II) ... 

When a 45-year-old man with severe lithium-induced diabetes insipidus developed hyperosmolar, nonketotic hyperglycemia, it was suggested that poorly controlled diabetes mellitus may have contributed to the polyuria (684). Prior contact with a female patient who had developed hyperosmolar coma secondary to lithium-induced diabetes insipidus (685) allowed physicians 4 years later to treat her safely after a drug overdose and a surgical procedure, by avoiding intravenous replacement fluids with a high dextrose content (despite stopping lithium several years earlier, the patient continued to put out 10 liters of urine daily) (686). 

Diabetes mellitus Thiazide diuretics, furosemide, corticosteroids, oral contraceptives Hyperglycemia aggravates diabetic control... 

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