DHEAS

DHEA(23) 4-Androstene-3,17-dione —> Estrone (26) Estrogens Cortisone (31)... 

Fig. 9. Abbreviated steroid biosynthesis where DHEA = dehydroepiandrosterone and DHT = dihydrotestosterone.

DHEAS decreased by 5.1 To ensure that this does not confound intervention studies, it would be sensible for future studies to utilise diets that are isocalorihc. 

DHEA Dehydroepiandrosterone SHBG Sex hormone-binding globulin... 

The major androgen or androgen precursor produced by the adrenal cortex is dehydroepiandrosterone (DHEA). Most 17-hydroxypregnenolone follows the glucocorticoid pathway, but a small fraction is subjected to oxidative fission and removal of the two-carbon side chain through the action of 17,20-lyase. The lyase activity is actually part of the same enzyme (P450cl7) that catalyzes 17tt-hydroxylation. This is therefore a dual function protein. The lyase activity is important in both the adrenals and... 

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate, its sulphated derivative... 

The neurosteroids of most interest are DHEA, PREG, PREGS, PROG and 3a5aThPROG. 

The researeh on dehydroepiandrosterone (DHEA) is limited beeause of the laek of radiolabeled metabolites. Robinzon et al. [126] showed that, using pig liver mierosomes, the radiolabeled metabolites of DHEA can be prepared in stable, pure form for bioehemical smdies. They utilized pig liver microsomal (PLM) fractions to prepare pH]-labeled 7a-hydroxy-DHEA (7a-OH-DHEA), 7[3-hydroxy-DHEA (7P-OH-DHEA), and 7-oxo-DHEA substrates from 50 pM [1,2,6,7-3H]DHEA. The metabolites were separated by silica gel PLC plates using ethyl aeetate-hexane-gla-eial aeetic acid (18 8 , v/v) as the mobile phase, extracted with ethyl aeetate, and dried under a stream of nitrogen. The purity of markers was determined with the use of TLC and GC/MS. 

The zona reticularis produces the androgens androstene-dione, dehydroepiandrosterone (DHEA), and the sulfated form of dehydroepiandrosterone (DHEA-S). Only small amounts of testosterone and estrogen are produced in the adrenal glands. Androstenedione and DHEA are converted in the periphery, largely to testosterone and estrogen. 

Although controversial, consider giving DHEA 50 mg/day (in the morning) to female patients who do not experience an improvement in mood and well-being even with adequate glucocorticoid and mineralocorticoid replacement. 

Monitor serum DHEA-S (aim for the middle range of normal levels in healthy young people) and free testosterone level. 

CYP450 3A4, cytochrome P-450 subfamily 111A polypeptide 4 DHEA,... 

Dehydroepiandrostemne (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are the most abundant steroids secreted by the adrenal cortex under pituitary ACTH control (B5). Very little plasma DHEA(S) appears to be of testicular or ovarian origin. Physiologically, the concentration of DHEA(S) in the blood oscillates coincidentally with cortisol, consistent with the response of adrenal... 

Kullak-Ublick, G. A., et al. Dehydro-epiandrosterone sulfate (DHEAS) identification of a carrier protein in human liver and brain. FEBS Lett. 1998, 424, 173-176. 

OTHER DIETARY SUPPLEMENTS FOR WEIGHT LOSS Dehydroepiandosterone (DHEA)... 

DHEA is an adrenal hormone that is a precursor to the sex hormones testosterone and estrogen, as well as other hormones. DHEA is reported to increase testosterone and decrease total body fat, and also to have anabolic and anti-aging effects. The... 

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