Dehydroepiandrosterone sulfate DHEAS

Dehydroepiandrostemne (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are the most abundant steroids secreted by the adrenal cortex under pituitary ACTH control (B5). Very little plasma DHEA(S) appears to be of testicular or ovarian origin. Physiologically, the concentration of DHEA(S) in the blood oscillates coincidentally with cortisol, consistent with the response of adrenal... 

Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U et al. Dehydroepiandrosterone sulfate (DHEAS) identification of a carrier protein in human liver and brain. FEBS Lett 1998 424(3) 173-176. 

In some countries dietary supplements containing dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEAS) have been advertised with claims that they may be beneficial for a wide variety of ailments. However, there is a lack of any proven benefit from DHEA supplementation. 

Androstenedione, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) are other mildly androgenic compounds of secondary importance in males and females. The gonads and the adrenal cortex are capable of secreting androstenedione... 

The results of the blood tests on Vera Leizd showed that her level of testosterone was normal but that her serum dehydroepiandrosterone sulfate (DHEAS) level was significantly elevated. Which tissue was the most likely source of the androgens that caused Vera s hirsutism (a male pattern of secondary sexual hair growth) ... 

For chemically knockout animals, the specificity of the transporter inhibitor is a major concern. For example, GF120918, a potent inhibitor of both P-gp and BCRP, has been extensively used to understand the role of P-gp and Bcrp in vivo (Allen et ah, 2003 Jonker et ah, 2000 Polli et al., 2004). However, Hoffmaster et al. recently indieated that GF120918 interacts with at least three transporters in the liver two transporters at the canalicular membrane, P-gp and Bcrp, and an unknown efflux mechanism at the basolateral membrane (Hoffmaster et ah, 2004b). Subsequently, Lee et al. have demonstrated that there could be one or more GF120918-sensitive efflux transporters distinct from BCRP or P-gp in the BBB that may contribute to the brain efflux of dehydroepiandrosterone sulfate (DHEAS) and mitoxantrone in mice. Understanding the specificity of transporter inhibitors can assist in more accurately determining the role of a given transporter in vivo. 

Dehydroepiandrosterone sulfate (DHEA-S) is inversely associated with cardiovascular death in males but not females. DHEA-S correlated positively with HDL-C and negatively with LDL-C, and the mean atherogenic index in a cross-sectional study in men and women (345). An early cardiovascular involvement was detected in severely obese normoten-sive premenopausal women with hyperinsulinaemia and low DHEA-S, even in the absence of other well-known CVD risk factors (346). 

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