Dexketoprofen

The area of racemic switches where a single enantiomer is developed subsequently to a corresponding racemate which is already on the market has attracted much interest [7, 8]. A description of the preclinical and clinical development of dexketoprofen provides a detailed example of one of these racemic switches [21]. The regulations in Europe and the US both allow for the development of a single enantiomer from a racemate by the use of bridging studies between the old and new applications. One problem to be considered is how a company which was not responsible for the original development can provide equivalent data. 

Dexketoprofen Gel Non-destructive drug quantitation method of a hydrogel in transflectance mode 35... 

M. Blanco and M.A. Romero, Near infrared transflectance spectroscopy. Determination of dexketoprofen in a hydrogel, J. Pharm. Biomed. Anal., 30, 467-472 (2002). 

Hanna MH et al Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery. Br J Clin Pharmacol 2003 55 126. [PMID 12580983]... 

Dexketoprofen Gel PLS Non-destructive quantitation method. Errors less than 0.8% 58... 

PROBENECID ANALGESICS - NSAIDS Probenecid t levels of indometacin and ketorolac and possibly dexketoprofen, ketoprofen, naproxen, tenoxicam and tiaprofenic acid Probenecid competitively inhibits renal metabolism of these NSAIDs Watch for signs of toxicity of these NSAIDs. Consider using an alternative NSAID. The manufacturers of ketorolac advise avoiding co-administration of ketorolac and probenecid... 

Photocontact dermatitis has been reported after topical application of dexketoprofen (Enangel), with positive photopatch tests to dexketoprofen 1% and piketoprofen 2% (190). 

Valenzuela N, Puig L, Barnadas MA, Alomar A. Photocontact dermatitis due to dexketoprofen. Contact Dermatitis 2002 47(4) 237. 

Omeprazole (Losec) Bupivacaine (Sensorcaine) Ketoprofen (Orudis) Ofloxacin (Floxin) Cetirizine.HCl (Zyrtec) AstraZeneca AstraZeneca Wyeth Ortho-McNeil Pfizer Esomeprazole (Nexium) Levobupivacaine (Chirocaine) Dexketoprofen (Enantyum) Levofloxacin (Levaquine) Levocetirizine (Xyzal) AstraZeneca Chirosdence Menarini Ortho-McNeil Sepracor... 

Propionic acid derivatives Dexketoprofen, Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Oxaprozin, Tiaprofenic acid... 

A small reduction in ketoprofen absorption occurred with aluminium-magnesium hydroxide, but dexketoprofen, ibuprofen and flurbiprofen were not affected, and naproxen showed a slight increase in rate and extent of absorption. Aluminium phosphate had no effect on ketoprofen absorption. 

In 24 healthy subjects an aluminium/magnesium hydroxide antacid (Maalox) had no effect on the rate or extent of absorption of a single 25-mg dose of dexketoprofen, although the maximum level was slightly (13%) lower. ... 

Dexketoprofen. The absorption of a single 25-mg dose of dexketoprofen was delayed by food (maximum level redueed by 45% and time to maximum level delayed by about 1 hour), but the AUC was not affected. ... 

Probenecid reduces the clearance of dexketoprofen, diflunisal, in-dometacin (toxicity seen), ketoprofen, ketorolac, naproxen, sodium meclofenamate, tenoxicam and tiaprofenic acid and raises their levels. Ketorolac and probenecid are specifically contraindicated. The uricosuric effects of probenecid are not affected by in-dometacin but may be slightly reduced by sulindac. 

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