Probenecid Dexketoprofen

PROBENECID ANALGESICS - NSAIDS Probenecid t levels of indometacin and ketorolac and possibly dexketoprofen, ketoprofen, naproxen, tenoxicam and tiaprofenic acid Probenecid competitively inhibits renal metabolism of these NSAIDs Watch for signs of toxicity of these NSAIDs. Consider using an alternative NSAID. The manufacturers of ketorolac advise avoiding co-administration of ketorolac and probenecid... 

Probenecid reduces the clearance of dexketoprofen, diflunisal, in-dometacin (toxicity seen), ketoprofen, ketorolac, naproxen, sodium meclofenamate, tenoxicam and tiaprofenic acid and raises their levels. Ketorolac and probenecid are specifically contraindicated. The uricosuric effects of probenecid are not affected by in-dometacin but may be slightly reduced by sulindac. 

In 6 healthy subjects probenecid 500 mg every 6 hours reduced the clearance of ketoprofen 50 mg every 6 hours by 67%4 The manufacturer of dexketoprofen notes that plasma levels may be increased by probenecid, and adjustment of the dose of dexketoprofen is required. ... 

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See also in sourсe #XX -- [ ]

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