AstraZeneca library

Figure 2.33. A fragment analysis application developed by AstraZeneca by integrating Fragmenter and Marvin in Spotfire. The application provides integrated views on hit frequencies of the fragments from a library in various targeted compound collection spaces. The structure and hit frequencies for the fragments are displayed in the lower-right corner while the user can interactively click one fragment dot or select a set of fragments. This screenshot is provided by Paul Xie of AstraZeneca...

Kogej, T., Blomberg, N., Greasley, P., Mundt, S., Vainio, M.J., Schamberger, J., Schmidt, G., and Huser, J. (2013) Big pharma screening collections more of the same or unique libraries The AstraZeneca-Bayer Pharma AG case. Drug Discovery Today, 18, 1014-1024. 

Additional screening has since been conducted with compound libraries from AstraZeneca, Pfizer, Sanofi, Evotec, Genzyme, the UK MRCT, the Biofocus Soft focus collection, and the Broad Institute. The summary of the published data is shown in Table 24.1. 

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