Dexamethasone poly

Immunoaffinity procedures have also been developed to selectively extract corticosteroids from different sample matrices. Thus, Seymour et al. demonstrated the higher efficiency of the immunoaffinity methods compared with the conventional extraction procedures using organic solvents [177]. Immunosorbents have also been used for online procedures followed by HLPC-UV [178, 179], HPLC-APCI-MS [179,180], GC-MS [176,181], or capillary electrophoresis [182]. Poly(hydroxyethyl methacrylate) (HEMA) was evaluated as a support material for the anti-dexamethasone antibodies used in IAC. The online IAC-HPLC-MS allowed determination of dexamethasone and flumethasone in equine urine with LODs in the range 3-4 ng mL-1 [180]. The cross-reactivity values obtained in the ELISA and the recoveries of an IAC-HPLC procedure are presented in Table 7. Bagnati et al. developed an immunoaffinity extraction... 

Einmahl, S., Zignani, M., Varesio, E., Heller, J., Veuthey, J.L., Tabatabay, C., and Gumy, R. (1999). Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly(ortho ester). Int. J. Pharmaceut., 185, 189-198. 

Abbreviations CEL, cellulose DXM, dexamethasone EIPA, ethylisopropylamiloride FIB, fibrin MR methylprednisolone NA, not available Neo-R, neointima reduction PC, phosphorylcholine PCL, polycaprolactone PFM-P75, polyfluoroalkoxyphosphazene PLLA(PLA), poly-L-lactic acid POP, polyorganophosphazene PU, polyurethane Q-DL, Quanam drug eluting stent Q-M, Quanam metal stent SNR sodium nitroprusside TIMP, tissue inhibitors of metalloproteinase. 

Poly-L-lactic acid Dexamethasone Porcine coronary (34,77)... 

At present a few studies of nanofibers and nanombes are focused on CNS drug delivery. One study evaluated electrospun nanofibers of a degradable polymer, PLGA, loaded with antiinflammatory agent, dexamethasone, for neural prosthetic applications (Abidian and Martin, 2005). A conducting polymer, poly(3,4-ethylenedioxythiophene), was deposited to the nano-fiber surface and the coated nanofibers were then mounted on the microfabricated neural microelectrodes, which were implanted into brain. The drug was released by electrical stimulation that induced a local dilation of the coat and increased permeability. 

Campos D, Pereira JR, Reinhardt RR, Carracedo C, Poli S, Vogel C, Martinez-Cedillo J, Erazo A, Wittreich J, Eriksson LO, Carides AD, Gertz BJ. Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granise-tron and dexamethasone or with dexamethasone alone. J Clin Oncol 2001 19(6) 1759-67. 

Figure 15.5 Left SEM image ofPEDOT nanotubes on a neural probe tip Right mass release of dexamethasone from poly(lactide-co-glycolide) (PLGA) fibers (black), PEDOT-coated PLGA nanoscale fibers without electrical stimulation (red), and PEDOT-coated PLGA nanoscale fibers with electrical stimulation of 1 Vat the times with the circled data. (Reprinted with permission from Advanced Materials, Conducting-polymer nanotubes for controlled drug release by M. R. Abidian, D.-H. Kim and D.C. Martin, 18, 4, 405-409. Copyright (2006) Wiley-VCH)...

A. Choksi, K.V. Sarojini, P. Vadnal, C. Dias, P.K. Suresh, J. Khandare, Comparative anti-inflammatory activity of poly(amidoamine) (PAMAM) dendrimer-dexamethasone conjugates with dexametha-sone-liposomes, Int. J. Pharm. 449 (1-2) (2013) 28-36. 

S.D. Patil, F. Papadimitrakopoulos, D.J. Burgess, Dexamethasone-loaded polyOactic-co-glycolic) acid microspheres/poly(vinyl alcohol) hydrogel composite coatings for inflammation control. Diabetes Technol. Ther. 6 (6) (2004) 887-897. 

The self-association of ELPs is starting to be employed to develop different applications. For example, Molina el al. [127] have tested self-assembled nano- and microparticles of poly(VPAVG), another version of ELP, as carriers of the model drug dexamethasone phosphate in order to develop injectable systems for controlled drug release. In these particles, the drug is entrapped while the particles self-assemble as the temperature rises above its Tt. 

Permanent and biocompatible stent coatings based on poly(/7-xylylene) films have been investigated for their potential to form drug-containing reservoirs [77]. Dexamethasone was used as a model drug and loaded into the poly(/ -xylylene) films. 

A linear release of dexamethasone was observed when the films were coated by an additional poly(p-xylylene) film as cover layer. 

Hanefeld P, Agarwal S, Kumar R, Greiner A. In vitro study of dexamethasone release from poly(p-xylylene) films. Macromol Chem Phys 2010 211(2) 265-9. 

Massoumi and Entezami [92] reported the controlled release of dexamethasone sodium phosphate (DMP) from a conducting polymer bilayer film consisting of a PPy inner film doped with DMP and poly(N-methylpyrrole)/polystyrene sulfonate (PNMP/PSS) or polyaniline sulfonate (SPANI) outer film. DMP was released from the inner film by an application of less than —0.6 V. In this device, the outer polymer layer functions as an ion and solvent barrier and also effectively reduces the rate of DMP release under an applied reducing electrochemical field, thereby providing an additional route to controlling release rates. 

Poly(ADP ribose) polymerase activity versus amounts of poiy(ADP> ribose) in differentiating 3T3-L1 cells. en confluent 3T3-L1 cells were treated with insulin, dexamethasone and methylisobutylxanthine and then with insulin alone, they differentiated within about 6 days to adipocytes (13). Beginning with day 4, enzymes of the adipocyte phenotype like glycerophosphate dehydrogenase were induced from low basal levels to high activities and the cells started to acciunulate large amoimts of fat which are deposited in the form of droplets. When we analyzed intrinsic poly(ADP-ribose) polymerase activity in permeabilized cells, a rise of activity was... 

Fig. 1. Poly(ADP-ribose) polymerase activity and poly(ADP-ribose) levels during differentiation. Cells were grown to confluence and initiated with insulin/dexamethasone/methylisobutylxanthine as described in (12). Poly(ADP-ribose) polymerase activity was determined in permeabilized cells, and poly(ADP-ribose) levels were quantiated (15) after TCA precipitation of cell cultures in situ.

Zhang Z, Grijpma DW, Feijen J (2006) Poly (trrmethylene carbonate) and monomethoxy poly (ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone. J Control Release 111 263-270... 

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