DEVELOPMENT OF LOW-DOSE FORMULATIONS USING FLUIDIZED BED GRANULATION

DEVELOPMENT OF LOW-DOSE FORMULATIONS USING FLUIDIZED BED GRANULATION 

Engineering Technology Center, Eli Lilly and Company, Indianapolis, IN 40285 RALPH LIPP 

Formulation and Analytical Development for Low-Dose Oral Drug Products. Edited by Jack Zheng Copyright 2009 John Wiley Sons, Inc. 

This chapter focuses on the use of fluidized bed granulation process in the development and preparation of low-dose granule formulations for further conversion to immediate release tablets for personal administration. As a reference document, the chapter does not cover some very common subjects such as process safety, material characterization techniques and basic process and instrumentation technologies. Because the authors intention is to relate their experience in this specialized area, these areas are not discussed in any depth however their omission does not reduce their importance. 

---