Carbohydrate-sulfotransferases

The similarities concerning the bound cofactors, the reaction mechanism, and the adenine-binding pockets led to a screen of the above-described purine-based library of ATP-competitive inhibitors originally designed to target CDKs for crossreactivity with the carbohydrate sulfotransferase NodH from Rhizobium meliloti. 

The library was also tested with murine estrogen sulfotransferase (mEST). This screen afforded a purine-based inhibitor of mEST with nanomolar potency that displayed weak activity against several CDKs and selectivity for mEST when tested with representative members of the carbohydrate sulfotransferase family [63], Finally, a screen of the library against P-arylsulfotransferase-IV (P-AST-IV) led to the discovery of a potent, highly selective inhibitor (26, Scheme 14.7) of P-AST-IV (X = 96 nM). This compound was also screened against a variety of nucleotidebinding proteins (several kinases, sulfotransferases, and others) and proved to be selective [64],... 

Niel F, Ellies P, Dighiero P, Soria J, Sabbagh C, San C, Renard G, Delpech M, Valleix S. Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy. Invest Ophthalmol Vis Sci 2003 44 2949-2953. 

Hemmerich S, Rosen SD. Carbohydrate sulfotransferases in lymphocyte homing. Glycobiology 2000 10 849-856. 

The above speculations are based on limited information. With the availability of an increasing number of cDNAs encoding carbohydrate sulfotransferases, rapid... 

K. G. Bowman, C. R. Bertozzi, Carbohydrate sulfotransferases mediators of extracellular communication. Chem. Biol 1999 6, R9 R22. 

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