Developing agents high-definition

Because of the presence of the cyclic four-membered amide connected to the multicyclic ring systems, an effort to define their mechanism of action would be highly important. Despite a number of synthetic efforts, a relatively small amount of research had been focused on the use of compounds related to PAHs as anticancer agents. Bair et al. [152, 153] reported a close correlation between antitumor activity and the shape of the polyaromatic system. However, his group did not make a definitive correlation between the ability of these compounds to bind to deoxyribonucleic acid (DNA) and their cytotoxic activity. Bair s group developed... 

The two populations of 5-HT receptors that have been definitely linked to depression are the 5-HT, and the 5-HT receptors. Numerous 5-HT, antagonists are available and belong to a multitude of chemical classes structure-activity relationships are well beyond the scope of this chapter and several reviews are available (e.g., 151,210,211). 5-HT, receptors consist of three families 5-HT , S-HTgB, and 5-HT . An important issue at this time is which one (or more) of these subpopulations is most involved in depression. This question remains to be answered. Another issue is that 5-HT receptors have been linked to cardiac valvulopathy (212). Hence, future development of 5-HT, ligands might wish to avoid agents with high affinity for 5-HT receptors. 

The term chemical warfare agents ideally would comprise all toxic chemicals that have been developed, produced, or used in a military context with the intention of utilizing its toxicity to man, animals or plants as its primary weapons characteristic. This definition excludes a considerable number of toxic chemicals used in a military environment, which serve other purposes a case in point is rocket fuel, which is highly toxic, but whose primary purpose is the propulsion of a missile. On the other hand, this definition goes beyond that used in the Chemical Weapons Convention (CWC) according to the CWC s Article II, para. 2 only those chemicals which through its chemical action on life processes can cause death, temporary incapacitation or permanent harm to humans or animals (emphasis added)1 count as chemical warfare agents. 

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