Mass spectrometry amide deuterium exchange

Woods, V.L. Jr. Hamuro, Y High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and... 

Woods V.L. Jr Dissecting interdomain communication within cAPK regulatory subunit type llbeta using enhanced amide hydrogen/ deuterium exchange mass spectrometry (DXMS). Protein Sci. 

Jr Mapping intersubrmit interactions of the regulatory subunit (Rla) in the type 1 holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J. Mol. Biol. 2004, 340, 1185-1196. 

Higher-Order Structure and Dynamics of FK506-Binding Protein Probed by Backbone Amide Hydrogen/Deuterium Exchange and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry... 

Coales, S.J., E, S.Y., Lee, J.E., et al. (2010) Expansion of time window for mass spectrometric measurement of amide hydrogen/deuterium exchange reactions. Rapid Communications in Mass Spectrometry, 24 (24), 3585-3592. 

J. D. Venable, L. Okach, S. Agarwalla and A. Brock. (2012) Subzero Temperature Chromatography for Reduced Back-Exchange and Improved Dynamic Range in Amide Hydrogen/Deuterium Exchange Mass Spectrometry, Ana/ytica/ Chemistry, 84 (21), 9601-9608. 

Zhang, Z., Li, W., Li, M., et al. (1997) Higher-order structure and dynamics of EK506-binding protein probed by backbone amide hydrogen/deuterium exchange and electrospray ionization Eourier transform ion cyclotron resonance mass spectrometry. Tech Protein Chem VIII, 703-713. 

Kim, M.Y., Maier, C.S., Reed, D.J., Deinzer, M.L. (2001) Site-specific amide hydrogen/deuterium exchange in E. coli thioredoxins measured by electrospray ionization mass spectrometry. J Am Chem Soc, 123 (40), 9860-9866. 

Landgraf, R.R., Chalmers, M.J., Griffin, P.R. (2012) Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution. J Am Soc Mass Spectrom, 23 (2), 301-309. 

Pandit, D., Tuske, S.J., Coales, S.J., et al. (2012) Mapping of Discontinuous Conformational Epitopes by Amide Hydrogen/Deuterium Exchange Mass Spectrometry and Computational Docking. Journal of Molecular Recognition, 25 (3), 114—124. 

Zhang, Q., Willison, L.N., Tripathi, R, etcd. (2011) Epitope Mapping of a 95 kDaAntigen in Complex with Antibody by Solution-Phase Amide Backbone Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Analytical Chemistry, 83 (18), 7129-7136. 

Coales, S.J., Tuske, S.J., Tomasso, J.C., Hamuro, Y. (2009) Epitope Mapping by Amide H/Deuterium Exchange Coupled with ImmobUization of Antibody, On-line Proteolysis, Liquid Chromatography and Mass Spectrometry. Rapid Communications in Mass Spectrometry, 23 (5), 639-647. 

Sharma, S., Zheng, H., Huang, Y.J., et al. (2009) Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry. Proteins, 76 (4), 882-894. 

Guo, M. Huang, B.X. Kim, H.Y. Conformational Changes in Aktl Activation Probed by Amide Hydrogen/Deuterium Exchange and Nano-Electrospray Ionization Mass Spectrometry. Rapid Com-mun. Mass Spectrom. 2009, 23, 1885-1891. 

Figure 6 Deuterium incorporation into specific segments of cytochrome C as a function of temperature, showing thermal melting at 58-64°C of a-helical regions. Reproduced with permission of Cambridge University Press from Zhang Z and Smith DL (1993) Determination of amide hydrogen exchange by mass spectrometry A new tool for protein structure elucidation. Protein Science 2 522-531.

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