Detoxification activity

Bafana A, Chakrabarti T, Devi SS (2008) Azoreductase and dye detoxification activities of Bacillus velezensis strain AB. Env Biotechnol 77 1139-1144... 

The following section discusses the different types and phases of microbial degradation of organic pollutants present at aqueous-solid phase interfaces. This includes a discussion of growth-linked biodegradation, acclimation, detoxification, activation, defusing, threshold, and co-metabolism. 

Cytotoxic activity. Water extract of the dried root, in cell culture, was inactive on CA-9KB, ED50greater than 0.1 pg/mL The methanol extract was active on Leuk-P388, ED50 0.57 pg/mL L Detoxification activity. Phenolic resin, in increasing levels, was mixed with alfalfa pellets and fed to wood rats. Three detoxification pathways and urine pH, which are related to detoxification of allelochemicals, were measured. The excretion rate of two-phase II detoxification conjugates, glucu-... 

Liver Acute liver failure Porcine hepatocytes Polysulfone hollow fiber Extracorporeal support device Detoxification activity, bridge-to-transplantation [20]... 

Figure 3 Schematic presenting multiple effects of Pluronic block copolymers displayed in MDR ceU. These effects include (a) decrease in membrane viscosity ( fluidization ) (b) ATP depletion (c,d) inhibition of drug efflux transport systems (e) reduction in GSH/GST detoxification activity and (f) drug release from acidic vesicles in the cell. Effects of Pluronic block copolymers on apoptosis (g) are not sufficiently studied at present. (From Ref. 94.)...

Cyanidin, delphinidin, petunidin, peonidin, pelargonidin, and malvidin are the most common anthocyanins in nature [125]. Their antioxidant, antiinflammatory, and detoxification activities justify their preventive roles against cancer and cardiovascular diseases. 

De Bartolo et al. reported the viability of human hepatocytes in a multibore hollow-fiber bioreactor and their liver specific functions, when human hepatocytes were cultured in the intraluminal compartment of the bioreactor. Human hepatocytes maintained their round shape on the membranes and showed focal adhesions as sites of interaction with the membrane surface they expressed fiver functions, including synthetic and detoxification activity. The results demonstrated that human hepatocytes cultured in the multibore fiber bioreactor are able to sustain the same in vivo fiver functions in vttro. ... 

It is well known that different species show different de-epoxidation efficiencies, but this capability in humans is quite low. In particular, from the data reported in the literature, it could be argued that the pre-exposure of the microbiota to DON is a key factor for inducing the appearance of the bacterial detoxification activity, either through the induction of the expression of particular enzymes and/or the selection of particular detoxifying bacterial species. According to very recent studies, experiments conducted with human feces from five volunteers showed that only one spontaneously possessed bacteria able to transform DON in DOM-1. 

Detoxification. Activated charcoal and saline cathartics for oral rlecontamination are helpful, but may be difficult to administer on a herd basis. 

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