Design tolerance guide

DESIGN FEATURES THAT INFLUENCE PERFORMANCE 865 Table 11-8. Tolerance Guide for Wall Thicknesses in High-Pressure Molding Processes ... 

Design of petrochemical facilities for accidental explosions is similar in many ways to design of facilities Tor high explosive detonations, nuclear weapons effects and nuclear power accidents for which design guides arc available. However, blast design for petrochemical plants is different in that more structural damage may be tolerated, in accordance with a company s blast protection philosophy. 

When the patients who received a drug candidate have the disease manifestations completely eradicated and experience no other effects while patients treated with a placebo have a continuation of the disease process, the evaluation is not difficult. However, that is rarely, if ever, the case, and evaluation requires detailed statistical analysis of the collected data. An ICH guide-line covers statistical issues related to the scope of clinical trials, design techniques to minimize bias, types of clinical trial designs, conduct considerations, data analysis for efficacy, evaluation of safety and tolerance, and reporting. 

Hackstein H, Morelli AE, Thomson AW. Designer dendritic cells for tolerance induction guided not misguided missiles. Trends Immunol 2001 22 437-442. 

Control is through adjusters and the shut-off rods. These are of simple design with relatively large tolerances (e.g., loose fit in guide tubes). They do not interact with the fuel... 

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