Optimization mixture design statistical technique

Glajch, J. L., Kirkland, J. J., Squire, K. M., and Minor, J. M., Optimization of solvent strength and selectivity for reversed-phase liquid chromatography using an interactive mixture-design statistical technique, /. Chromatogr., 199, 57, 1980. 

Glajch, J.L. Kirkland, J.J. Snyder, L.R. Practical optimization of solvent selectivity in liquid-sohd chromatography using a mixture-design statistical technique. J. Chromatogr. 1982, 238, 269-280. 

Figure 4.28. Separation of nine substituted naphthalene compounds using the mixture-design statistical technique to optimize the composition of the mobile phase (From ref. [375] John Wiley Sons).

A four-solvent optimization procedure that uses the mixture design statistical technique was applied by Coenegracht et al. [30]. 

The mixture design statistical technique can be used for other parameters besides solvent composition. In this way, a multifactor optimization system was introduced in TLC, by which the plate length, binary solvent composition and analysis time in continuous-development TLC was optimized. 

Optimization, 81-99 general methods of, 81-92 mixture design statistical technique, 88-91 multifactor optimization system, 91-92 the PRISMA method, 86-88 simplex optimization, 83-86,87 window diagrams, 81-83 miscellaneous methods of, 92-97 stepwise gradient optimization, 95-96 two-dimension optimization, 92-95,96 unknown component optimization, 97 of the mobile phase, 23-25 Organochlorine (OC) insecticides color reactions of, 805... 

Adequate resolution of the components of a mixture in the shortest possible time is nearly always a principal goal. Establishing the optimum conditions by trial and error is inefficient and relies heavily on the expertise of the analyst. The development of computer-controlled HPLC systems has enabled systematic automated optimization techniques, based on statistical experimental design and mathematical resolution functions, to be exploited. The basic choices of column (stationary phase) and detector are made first followed by an investigation of the mobile phase composition and possibly other parameters. This can be done manually but computer-controlled optimization has the advantage of releasing the analyst for other... 

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