Design process Partitioning

Absorption, in general, is treated as a physicochemical transport process based on computations of logP (the octanol/water partition coefficient) and solubility governed by factors such as polar surface area on the molecule. It is conceivable that SNPs in drug transporter genes will affect the pharmacokinetic properties of compounds and, therefore, these may have to be taken into consideration in the design process. 

The requirements for the partitioning mechanisms should be determined as part of the design process and are typically derived from the results of partitioning analysis. The general approach for condncting partitioning analysis is as follows ... 

In summary, the size exclusion of macromolecules in absence of any energetic interactions with the column packing is an entropy controlled process. It is based on the distribution of solute molecules between two volumes of eluent - that is between the interstitial volume and the pore volume within column. According to the terminology of physical chemistry, such process is to be designated the partition and because the present one is controlled by entropy, it should be termed the entropic partition. 

H. Nelis and E. Deprettere. Automatic design and partitioning of systolic/wavefront arrays for VLSI. Circuits, Systems and Signal Processing, 7, number 2, pages 235-252, 1988. 

If the partitioned design were to be implemented as separate processes, the same number of functional units would be needed as is used for the single process partitioned design. 

In SuperPro Designer, the partition factor of the solvent should be specified along with the solubility of light- and heavy-phase solvents as previously shown in Example 8.1. A process flow sheet and streams components mass flow rates are shown in Figure 8.26. 

Multicomponent systems containing four or more components become difficult to display graphically. However, process-design calculations can often be made for the extraction of the component with the lowest partition ratio K and treated as a ternaiy system. The components with higher K values may be extracted more thoroughly from the raffinate than the solute chosen for design. Or computer calculations can be used to reduce the tedium of multicomponent, multistage calculations. 

Cylinders within workplaces should be restricted to those gases in use. Specially designed compartments with partitions may be required to protect people in the event of explosion. Take into account emergency exits, steam or hot water systems, the proximity of other processes etc. Consider the possibility of dense gases accumulating in drains, basements, cable ducts, lift shafts etc. 

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