Single-Pot Processing

Pearlswig DM, Robin P. Lucisano LJ. Simulation modeling applied to the development of single pot processing using microwave drying. Pharm Technol 1994 18 44-60. 

Danheiser used retro-1,2-Brook rearrangement of allyl silyl ethers in a convenient route to a,/ -unsaturated acyl silanes. For example, 2-methyl-2-propen-l-ol was converted to the trimethylsilyl ether and, in a single-pot process, deprotonated by addition of 1.2 equiv terr-butyllithium. Protonation with a solution of acetic acid in tetrahydrofuran gave the of-hydroxyallylsilane 144. Removal of volatiles from the thermally sensitive product provided 95-percent-pure material that was oxidized to the a,P-unsaturated acyl silane 145 under Swem conditions. ... 

The systems exhibit a high simplicity and provide the oxidized and carboxylated (carboxylic acids) products in a single-pot process, thus contrasting with the higher complexity of the industrial synthetic processes for the same products. 

Over the last 30 years since its introduction, single-pot processing has developed into a mature and generally accepted production technique. 

Even if the technique historically was often used because of its specific advantages for effervescent production, potent compounds, organic solvents, or multiproduct facilities, practice has shown that single-pot processing is also attractive for standard pharmaceutical solid dosage production. 

Pearlswig DM. Simulation Modeling Applied to the Single Pot Processing of Effervescent Tablets. Master s Thesis, North Carolina State University, Raleigh, NC. 

Indicate one or more satisfactory oxidants for effecting the following transformations. Each molecule poses problems of selectivity or the need to preserve a potentially sensitive functional group. In most cases a single pot process is possible and in no case is more than three steps required. Explain the basis... 

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