Descriptive Examples

DNA Strand in orange ribbon. Protein in green cartoon. 

GCT-GCG-3 over the nonpermuted site. The results indicated that observations on the specihcity of zinc hngers can be extended to generalized zinc-finger structures and realized the use of zinc fingers for the design of site-specific DNA-binding proteins.  

Various other research groups have been working since the early 1990s toward rule formation for zinc-finger proteins and their interactions with DNA. Researchers believe that there are key amino acid positions on the zinc-finger protein that interact with base or phosphate positions on DNA in similar ways for different zinc-finger-DNA systems. These positions may form 

TABLE 2.4 Selected Bond Lengths for the Tramtrack Zinc-Finger Protein 

Lippard, Stephen J. Berg, Jeremy, M. Principles of Bioinorganic Chemistry, University Science Books, Mill Valley, CA, 1994. 

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Species type Structure Description Example Bond angles... 

Process Short process description Examples of plants... 

In this text, iron-sulfur clusters are discussed because they appear in proteins and enzymes (1) cytochrome b(6)f, Rieske [2Fe-2S] cluster (Section 7.5 and Figure 7.26) (2) cytochrome bci, Rieske [2Fe-2S] cluster (Section 7.6 and Figure 7.30) and (3) aconitase, [4Fe-4S] cluster (Section 7.9.2.1, and Figure 7.50). The iron-sulfur protein (ISP) component of the cytochrome b(6)f and cytochrome bci complexes, now called the Rieske ISP, was first discovered and isolated by John S. Rieske and co-workers in 1964 (in the cytochrome bci complex). More information about the RISP is found in Section 7.5.1. Section 7.9.2 briefly discusses other proteins with iron-sulfur clusters—rubredoxins, ferrodoxins, and the enzyme nitrogenase. The nitrogenase enzyme was the subject of Chapter 6 in the hrst edition of this text— see especially the first edition s Section 6.3 for a discussion of iron-sulfur clusters. In this second edition, information on iron-sulfur clusters in nitrogenase is found in Section 3.6.4. See Table 3.2 and the descriptive examples discussed in Section 3.6.4. 

One large class of non-heme iron-containing biomolecules involves proteins and enzymes containing iron-sulfur clusters. Iron-sulfur clusters are described in Sections 1.7 (Bioorganometallic Chemistry) and 1.8 (Electron Transfer) as well as in Section 3.6 (Mossbauer Spectroscopy). See especially Table 3.2 and the descriptive examples discussed in Section 3.6.4. Iron-sulfur proteins include rubredoxins, ferrodoxins, and the enzymes aconitase and nitrogenase. The nitrogenase enzyme was the subject of Chapter 6 in the hrst edition of this text—see especially Section 6.3 for a discussion of iron-sulfur clusters. In this... 

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