DERMAL model

Further data on the permeability of PPE is needed for the DERMAL model [134],... 

Modeling Residential Re-entry Dermal Exposures 157 Integrated Physical-Stochastic Dermal Model 158 Macro-Based Dermal Exposure Methodology 159 Scenario 1 159... 

The transfer-factor-based dermal modeling approach can be illustrated for estimating potential post-application dermal contact with floor surfaces on which aerosols have deposited by using the Jazzercise study conducted by Ross et al. 

The following section presents a practical, integrated physical-stochastic dermal model that represents a synthesis of the above described approach (transfer-factor-based), and shows the relationship with another commonly used dermal exposure... 

THERdbASE contains two major modules, namely a Database Module and a Model Base Module. The Database Module relates information from exposure, dose and risk-related data files, and contains information about the following population distributions, location/activity patterns, food-consumption patterns, agent properties, agent sources (use patterns), environmental agent concentrations, food contamination, physiological parameters, risk parameters and miscellaneous data files. The Model Base Module provides access to exposure dose and risk-related models. The specific models included with the software are as follows Model 101, subsetting activity pattern data Model 102, location patterns (simulated) Model 103, source (time application) Model 104, source (instantaneous application) Model 105, indoor air (two zones) Model 106, indoor air (n zones) Model 107, inhalation exposure (BEAM) Model 108, inhalation exposure (multiple chemicals) Model 109, dermal dose (film thickness) Model 110, dose scenario (inhalation/dermal) Model 201, soil exposure (dose assessment). 

Table 43.2 shows the general model parameters (excluding dermal) used in this modeling example, and Table 43.3 shows the dermal model parameters. For all the equations, cross-references are provided to the relevant lines of the Matlab code... 

TABLE 43.2 PBPK Model Parameters Used in the Example Application, Exclnding the Dermal Model Parameters ... 

This Matlab code is for updating the PBPK model derivatives based on the dermal model options. 

Updates to the basic PBPKmodel derivative structure with dermal derivative % Inputs are same as the generic PBPK update derivatlve function % Output d amount - - derivative vec tor updatedwl th the dermal model equations... 

Myers SR, Grady J, Soranzo C, Sanders R, Green C, Leigh IM, Navsaria HA. A hyaluronic acid membrane delivery system for cultured keratinocytes clinical take rates in the porcine kerato-dermal model. J Burn Care Rehabil 1997 18 214-222. 

Figure 15.1 Layer-by-layer deposition to produce three-dimensional (3D) tissues, eg, in vitro skin. In (a) and (b) a diagram of printed 3D dermal models is shown (gray lines represent bioink layers and orange lines show cell suspension layers). The circular bioink layers on top serve as container for later keratinocyte seeding to generate the epidermis, (c) and (d) show dermal equivalents printed according to the scheme in (a) and (b). Scale in (c) and (d) = 2 mm. Reproduced with permission Rimann, M., Bono, E., Annaheim, H., Bleisch, M., Graf-Hausner, U., 2015a. Standardized 3D bioprinting of soft tissue models with human primary cells. J. Lab. Autom. http //dx.doi.0rg/lO.l 177/2211068214567146.

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