Derived Minimal Effect Level

RIP) suggest that factors representing these probabilities be incorporated into future assessments as a derived minimal-effect level (DMEL) for human health [126]. 

A DNEL is a Derived No-Effect Level and a DMEL is a Derived Minimal Effect Level. A DNEL applies to non-genotoxic substances and a DMEL to genotoxic carcinogens and substances sensitising by inhalation. Note the principal difference between the two approaches that is reflected in the terminology a DNEL is connected with absence of effect a DMEL is connected with a (low and accepted) effect level. 

Toxicologists generally posit that no threshold exists for some effects, notably for most carcinogens. Such effects are characterized by a derived minimal effect level (DMEL) in the European Union in the parlance used in the United States, risks are characterized using oral slope factors and oral or inhalation unit risks. A DMEL represents the exposure level that corresponds to a specified level of risk to the exposed population. In the case of a chemical known or suspected to be a human carcinogen, this exposure level corresponds to a risk of one excess case of cancer in an exposed population. For a hypothetically exposed population of one million people, for example, this risk level of one excess case of cancer in the population of one million is abbreviated... 

Where sufficient toxicologic information is available, we have derived minimal risk levels (MRLs) for inhalation and oral routes of entry at each duration of exposure (acute, intermediate, and chronic). These MRLs are not meant to support regulatory action but to acquaint health professionals with exposure levels at which adverse health effects are not expected to occur in humans. They should help physicians and public health officials determine the safety of a community living near a chemical emission, given the concentration of a contaminant in air or the estimated daily dose in water. MRLs are based largely on toxicological studies in animals and on reports of human occupational exposure. 

ATSDR derives minimal risk levels (MRLs) for non-cancer toxicity effects (e.g., birth defects or liver damage). The MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects over a specified duration of exposure. For inhalation or oral routes, MRLs are derived for acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more) durations of exposures. The method used to derive MRLs is a modification in the RfD methodology of the EPA. The primary modification is that the uncertainty factors of 10 may be lower, even down to 2 or 1, based on scientific judgment. These uncertainty factors are applied for human variability, interspecies variability... 

Minimal Risk Eevel Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. 

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