Deoxyribonucleic acid stability

The attachment of zinc to the phosphate groups and the subsequent cleavage of the phosphate bonds demonstrate the case opposite to Dr. Jones , in that metal ions are much more effective than protons in this cleavage reaction. Evidently this is caused by stabilization of the intermediate by chelation of the metal to the hydroxyl group as well as to the phosphate. In fact, deoxyribonucleic acid (DNA), which is like RNA except that it lacks the 2 -hydroxyl group, cannot be cleaved by metal ions. 

Marmur, J. and Doty, P. (1959). Heterogeneity in deoxyribonucleic acids. I. Dependence on composition of the configurational stability of deoxyribonucleic acids. Nature, 183, 1427-1429. 

Deoxyribonucleic acid (DNA) has limited chemical stability. As a result, oxidative damage, hydrolysis, and nonenzymatic DNA methylation occur in vivo at significant rates (L6). Thus, another aspect of this theory is that of intrinsic somatic mutations and the ability of cells to repair the damage to both mitochondrial and nuclear DNA. Indeed, mammalian cells have an elaborate system of DNA repair enzymes which become less efficient with time. Thus, failure to repair damaged DNA or to "misrepair it could lead to gene inactivation or possible excision of... 

From the survey of the above literature, it is concluded that only a limited work is done on such type of problems. In the present study, the stability of emulsion has been discussed in the light of Derjaguin, Landau, Vervey and Overbeek theory (8) using Deoxyribonucleic acid and ribonucleic acid as flocculants for the emulsion stabilized by the drug sulphapyridine. 

All these compounds are more similar to benzene in stability and chemical behavior than they are to the alkenes. Many of these compounds are components of molecules that have significant effects on biological systems. For instance, the purines and pyrimidines are components of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). DNA and RNA are the molecules responsible for storing and expressing the genetic information of an organism. The pyridine ring is found in... 

Chlorpromazine, which inhibited vasopressin release in the rat (Moses 1964), is an excellent electron donor and thus activated to a cation free radical by the myeloperoxidase system of the human neutrophil (Van Zyl et al. 1990). The relatively high stability of this radical is due to resonance stabilisation and the absence of a hydrogens. The radical ion interacted with deoxyribonucleic acid (Ohni-SHi and McConnell 1965). 

Polymer science is a specialized field concerned with the structures, reactions, and applications of polymers. Polymer scientists generate basic knowledge that often leads to various industrial products such as plastics, synthetic fibers, elastomers, stabilizers, colorants, resins, adhesives, coatings, and many others. A mastery of this field is also essential for understanding the structures and functions of polymers found in living things, such as proteins and deoxyribonucleic acid (DNA). 

Eichhom GL. Metal ions as stabilizers or destabilizers of the deoxyribonucleic acid strac-ture. Nature. 1962 194 474-5. 

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