Deoxyadenylate kinase

CARNOSINE SYNTHETASE CHAPERONES CHOLINE KINASE CHOLOYL-CoA SYNTHETASE COBALAMIN ADENOSYLTRANSFERASE 4-COUMAROYL-CoA SYNTHETASE CREATINE KINASE CTP SYNTHETASE CYTIDYLATE KINASE 2-DEHYDRO-3-DEOXYGLUCONOKINASE DEHYDROGLUCONOKINASE DEOXYADENOSINE KINASE DEOXYADENYLATE KINASE DEOXYCYTIDINE KINASE (DEOXYjNUCLEOSIDE MONOPHOSPHATE KINASE DEOXYTHYMIDINE KINASE DEPHOSPHO-CoA KINASE DETHIOBIOTIN SYNTHASE DIACYLGLYCEROL KINASE DIHYDROFOLATE SYNTHETASE DNA GYRASES DNA REVERSE GYRASE ETHANOLAMINE KINASE EXONUCLEASE V... 

DEOXYADENOSINE KINASE DEOXYADENYLATE KINASE DEOXYCYTIDINE KINASE DEOXYCYTIDYLATE HYDROXYMETHYL-TRANSFERASE Deoxycytidylate kinase,... 

Fractionation of extracts from calf thymus for kinase activity toward deoxyribonucleoside monophosphates has revealed the presence of at least four separate enzymes the kinase activities for dAMP, dGMP, dCMP, and dTMP are separate entities in this tissue 31). Each has been partly purified and examination of substrate specificities showed that the kinases for deoxyadenylate and deoxyguanylate also phosphorylate the ribosyl homologues, adenylate and guanylate, respectively. The deoxycytidylate kinase accepts as substrates both cytidylate and uridylate, but will not phosphor> late deoxyuridylate. The calf thymus thymidine monophosphate... 

As a further instance of a dual function for the nucleoside monophosphate kinases, separate kinases for adenylate-deoxyadenylate, guanylate-deoxyguanylate, cytidylate-deoxycytidylate, uridylate, and thynudylate have been demonstrated in E. cdi extracts (35) it should be noted that cytidylate-deoxycytidylate kinase and uridylate kinase were found as separate enzyme activities in the E. cdi experiments. 

Another instance of the induction of enzymes not ordinarily present in E. coli which occurs upon infection with bacteriophage T2 (see Section I, D and II, E) is found in the work of Bello and Bessman ( 4), who isolated from T2-infected E. coli, a deoxynucleoside monophosphate kinase with specificities quite distinct from those of the kinases discussed above. The phage-induced kinase is specific for deoxj/ribonucleoside monophosphates and will phosphorylate three of the four nucleotides destined for phage DNA deoxyguanylate, thymidylate, and hydroxymethyldeoxycyti-dylate. The enzyme does not phosphorylate deoxyadenylate. 

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