Deniker, Pierre

Dale, Sir Henry 77 Delay 77 Delay, Jean 77 delocalized orbitals 233 Deniker, Pierre 77 Density Functional Theory 55,228,241,271,278 deposition conditions 168 design of the Sawatzky-Kay apparatus 152 Dess-Martin oxidation 11 detailed atomic-level representation 92 determinant 279 diastereoface selectivity 22,... 

Chlorpromazine s (CPZ) efficacy was discovered primarily by chance in exploratory clinical trials after it had been initially synthesized as an antihistamine. Its discovery, however, was not entirely fortuitous, because it was chosen for human investigation since it was mildly sedating. The concept of an antipsychotic, however, was unknown. CPZ s sedative properties then led the French anesthesiologist and surgeon Henri Laborit to use it in a lytic cocktail to reduce autonomic response with surgical stress (1). He also persuaded many clinicians to try it for the treatment of a wide variety of other disorders. In this context, he encouraged John Delay and Pierre Deniker (1952), who then administered CPZ to schizophrenic patients. The rest is history ( 2, 3). 

Despite this evidence of the rapidity of the adoption of the new drugs and their influence on psychiatry, many of their advocates complained that there was resistance to using them. Pierre Deniker, one of the French psychiatrists who had first used chlorpromazine with psychiatric patients, complained in an interview in 1971 that this work had roused little interest (quoted in Swazey 1974, p. 138). Subsequently other prominent psychopharmacologists and historians of the period have reiterated this view (Healy 1996 Swazey 1974). Historian Judith Swazey s account of the introduction of chlorpromazine asserts that there was a general reluctance to... 

In 1952 a French surgeon, Henri Laborit, used chlorpromazine to aid anaesthesia in surgical operations. His description of its effects led French psychiatrists Jean Delay and Pierre Deniker to wonder about its... 

At the same conference Pierre Deniker and his colleague declared that... 

Psychiatrists have been using agents that are active in the central nervous system for hundreds of years. Stimulants and depressants were used to modify the mood and mental states of psychiatric patients. Amphetamine, sedatives, and hypnotics were used to stimulate or depress the mental states of patients. The synthesis of chlorpromazine by Charpentier ultimately caused a revolution in the treatment of schizophrenia, but who really discovered chlorpromazine Charpentier, who first synthesized the molecule in 1950 at Rhone-Poulenc s research laboratory Simon Courvoisier, who reported distinctive effects on animal behavior Henri Laborit, a French military surgeon who first noticed distinctive psychotropic effects in man or Pierre Deniker and Jean Delay, French psychiatrists who clearly outlined what has... 

The drug company. Smith Kline French, first marketed chlorpromazine as a treatment for vomiting. Clinical trials in patients with mental illness were then conducted in state mental hospitals by Pierre Deniker who obtained miraculous results. In 1954, two years after chlorpromazine, reserpine was introduced into dinical practice. 

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