Dendrimer high loading

Swali, V., Wells, N.J., Langley, G.J., and Bradley, M. (1997) Solid-phase dendrimer synthesis and the generation of super-high-loading resin beads for combinatorial chemistry. J. Org. Chem. 62, 4902-4903. 

Fig. 7.1 Schematic representation of linear versus dendritic polymers linear (left) and hyperbranched (middle) polymers, perfect dendrimer (right). The amount of terminal groups is indicated below each structure. These architectures can also be attached to a cross-linked polymer bead to obtain a high-loading hybrid material.

Dendrimers, among other applications, are generating interest as soluble supports thanks to the following intrinsic characteristics (i) the well-defined molecular composition of a dendrimer provides a support with a precisely defined arrangement of the reactive sites, (ii) a high loading of reactive sites is achieved on the dendrimer surface and (iii) nanofiltration techniques are available to separate the dendritic support from products. Dendrimer 143, based on a carbosilane core, possesses 12 ester functionalities on... 

Fromont, C., Bradley, M. High-Loading Resin Beads for Solid Phase Synthesis Using Triple Branching Symmetrical Dendrimers. Chem. Commun. 2000, 283-284. 

Haag R (2001) Dendrimers and hyperbranched polymers as high-loading supports for organic synthesis. Chem Eur J 7(2) 327—335... 

The class of so-called soluble supports, including PEGs, non-cross-linked PS, and the recently introduced high-loading dendrimers, will be covered in Section 8.5. 

The combinatorial assembly of isocyanate-decorated dendrimers was reported by Newkome et al. (93) as a method to modulate the solubility, reactivity and viscosity properties of such popular materials. This modulation has an obvious impact for the discovery of high loading, soluble and flexible supports for high throughput organic synthesis. 

Scheme 4 Synthesis of high-loading PS-aryl ether dendrimer hybrid supports...

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