Dendrimer biocompatible

Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 2005 57 2215-2237. 

Dendrimers can be used to effectively coat and passivate fluorescent quantum dots to make biocompatible surfaces for coupling proteins or other biomolecules. In addition, the ability of dendrimers to contain guest molecules within their three-dimensional structure also has led to the creation of dendrimer-metal nanoclusters having fluorescent properties. In both applications, dendrimers are used to envelop metal or semiconductor nanoparticles that possess fluorescent properties useful for biological detection. 

Shi, X., Wang, S., Sun, H., and Baker Jr., J.R. (2007) Improved biocompatibility of surface functionalized dendrimer-entrapped gold nanoparticles. Soft Matter 3, 71-74. 

Biocompatible nanosized polyamidoamine (PAMAM) dendrimer films provided a suitable microenvironment for heme proteins to transfer electron directly with underlying pyrolytic graphite electrodes. The Mb-PAMAM film can catalytically reduced oxygen, hydrogen peroxide, and nitrite, indicating that the potential applicability of the film can be used to fabricate a new type of biosensor or bioreactor based on the direct electron transfer of Mb [234],... 

See also Luminescent dendrimers antibacterial, 26 799 biocompatibility studies of, 26 800-801 in catalysis, 26 805-806 in cell targeting, 26 797-798 as chelators, 26 806-807 core and interior shells of, 26 789 cytotoxicity of, 26 800-801 in drug delivery, 26 792-795 in gene transfection, 26 791-792 as imaging agents, 26 795-797 luminescent, 26 801-804 medical applications of, 26 791-801 micelle-mimetic behavior of, 26 789 multiphoton applications of, 26 803-804... 

Biocompatible dendrimers were prepared by Tomalia et al. (4) and are discussed. 

Malik, N., et al. 2000. Dendrimers Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 1251-labelled polyamidoamine dendrimers in vivo. 

These dendrimers expand the repertoire of polymers available for study. Current investigations are primarily limited to linear polymers that possess ill-defined solution structures and fewer hydroxyl groups for further modification. The introduction of biocompatible building blocks (e.g., glycerol and lactic acid) augments the favorable and already known physical properties of dendrimers. These properties are likely to facilitate the design of new materials for specific biomedical and tissue engineering applications. 

In the hope of obtaining biocompatible dendrimers suitable for medical use in the prevention of infection, PAMAM dendrimers [33], polyether amide den-... 

Luo, D. Haverstick, K. Belcheva, N. Han, E. Saltzman, W.M. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery. Macromolecules 2002, 35, 3456-3462. 

Roberts, J.C. Bhalgat, M.K. Zera, R.T. Preliminary biological evaluation of polyamidoamine (PAMAM) star-burst dendrimers. J. Biomed. Mater. Res. 1996, 30, 53-65. Malik, N. Wiwattanapatapee, R. Klopsch, R. Lorenz, K. Frey, H. Weener, J.W. Meijer, E.W. Paulus, W. Duncan, R. Dendrimers relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of l-Labeled polyamidoamine dendrimers in vivo. J. Control. Release 2000, 65, 133-148. 

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