Biocompatible surfaces

Imanishi et al. [33] pointed out that there was an optimum point at which the tethering density of PEO chains makes a polybutadiene urethane surface biocompatible. They also reported that bovine plasma FGN and bovine y-globulin adsorbed on the PEO-modified polyurethane were completely denatured, in comparison with 4-38% denaturation of BSA adsorbed. 

Used to render surfaces biocompatible and resistant to protein adhesion copolymers with poly(propylene oxide) form thermoreversible gels for drug delivery... 

Zhang YZ et al (2005) Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts. Biomacromolecules 6(5) 2583-2589... 

Lian et al. [123] investigated the polysaccharides, hyaluronic acid (HA) and sulfonated hyaluronic acid (SHA), as a suitable biomolecule to improve the surface biocompatibility of PPy films. The biological activity of the HA-functionalized PPY film was assessed by means of an in vitro PC12 cell... 

Lloyd AW. Interfacial bioengineering to enhance surface biocompatibility. Med Device Technol. 2002 13 18-21. 

The surfaces of most biomaterials implanted in the body come in direct contact with the body s blood or other liquids. Thus, surface biocompatibility plays a crucial role in determining device performance (surface biocompatibility) during initial bioreactions at the material-body interface. Surface biocompatibility is either bioactive (specifically bioactive of the favorable body reaction) or bioinert (non-foreign-body reactions). 

P3HB discs implanted for 3 months in the peritoneum of rats showed the presence of a thin and poorly adherent fibrous capsule that contained no inflammatory cells. P3HB was assessed to be biocompatible because the formed capsule was porous and ensured communication between the polymer and the biological fluids. Perfluorohexane plasma-modified P3HB discs were surrounded by a nonporous capsule indicating a sHght decrease in the surface biocompatibility [139]. 

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