Death, reproductive

Toxicology Prolonged/repeated contact with sidn or eyes can cause irritation excessive inh. may cause nasal/respiiatoiy irritetion, CNS effects, possible unconsciousness, death, reproductive damage ing. of Ig. amts, may cause serious injury TSCA listed Precaution Incompat. with materials which react with water Hazardous Decomp. Prods. Hydrocarbon decomp, prods., silica HMIS Health 1, Rammability 1, Reactivity 0 borage Store below 100 F do not freeze mix well before use... 

Toxicology Prolonged/repeated contact with skin or eyes can cause irritation excessive inh. may cause nasal/respiratory irritation, CNS effects, possible unconsciousness, death, reproductive damage ing. of Ig. amts, may cause seri-... 

In laboratory tests, appHcation of DMAC to the skin of pregnant rats has caused fetal deaths when the dosages were close to the lethal dose level for the mother. Embryonal malformations have been observed at dose levels 20% of the lethal dose and higher. However, when male and female rats were exposed to mean DMAC concentrations of 31,101, and 291 ppm for 6 h per day over several weeks, no reproductive effects were observed (6). 

It is necessary to estabUsh a criterion for microbial death when considering a sterilization process. With respect to the individual cell, the irreversible cessation of all vital functions such as growth, reproduction, and in the case of vimses, inabiUty to attach and infect, is a most suitable criterion. On a practical level, it is necessary to estabUsh test criteria that permit a conclusion without having to observe individual microbial cells. The failure to reproduce in a suitable medium after incubation at optimum conditions for some acceptable time period is traditionally accepted as satisfactory proof of microbial death and, consequentiy, stetihty. The appHcation of such a testing method is, for practical purposes, however, not considered possible. The cultured article caimot be retrieved for subsequent use and the size of many items totally precludes practical culturing techniques. In order to design acceptable test procedures, the kinetics and thermodynamics of the sterilization process must be understood. 

This interference prevents cell reproduction, leading to death of the bacteria. 

Chapter 3 Health Effects Specific health effects of a given hazardous compound are reported by type of health (death, systemic, immunologic, reproductive), by route of exposure, and by length of exposure (acute, intermediate, and chronic). In addition, both human and animal studies are reported in this section. 

To help public health professionals and others address the needs of persons living or working near hazardous waste sites, the information in this section is organized first by route of exposure (inhalation, oral, and dermal) and then by health effect (death, systemic, immunological, neurological, reproductive, developmental, genotoxic, and carcinogenic effects). These data are discussed in terms of three exposure periods acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). 

Health Effect The major categories of health effects included in LSE tables and figures are death, systemic, immunological, neurological, developmental, reproductive, and cancer. NOAEEs and EOAELs can be reported in the tables and figures for all effects but cancer. Systemic effects are further defined in the "System" column of the LSE table (see key number 18). 

EPA (1989) also indicates that analysis of the diisopropyl methylphosphonate used in this study determined that it was only 65% pure. Therefore, results from the Army (1978) study are considered inappropriate for human health risk assessment. No deaths of adult rats were recorded in a three-generation study of reproductive effects in rats receiving diisopropyl methylphosphonate in the diet at 0, 30, or 300 mg/kg/day (Hart 1980). 

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