Death registry

At present it is not clear whether extreme agitation, delirium, hyperthermia, and rhabdomyolysis are effects of cocaine that occur independently and at random among cocaine users, or whether these features are linked by common toxicologic and pathologic processes.20 Ruttenber and colleagues20 have examined excited delirium deaths in a population-based registry of all cocaine-related deaths in Dade County. This study has led to clear description of the cocaine delirium syndrome, its pattern of occurrence in cocaine users over time, and has identified a number of important risk factors for the syndrome. 

Obstacles remained as PTCA was not universally available and often associated with considerable time delay, especially in off peak hours. In the National Registry of Myocardial Infarction-2 (NRMI-2 >27,000 patients), total ischemia time (symptom onset to balloon inflation) was 3.9 h with onset to hospital arrival 1.6 h [45]. Unadjusted in-hospital mortality was higher in patients treated later. Door to balloon time > 2 h was related to in-hospital death (41-62% adjusted odds increase) and centers who treat >3 STEMIs/month had improved in-hospital mortality compared to less experienced facilities (Figs. 5.4 and 5.5). Lastly, similar to trials of unstable angina, PTCA was plagued by high restenosis rates... 

Holmes DR, Kip KE, Kelsey SF, et al. Cause of death analysis in the NHLBI PTCA registry results and considerations for evaluating long-term survival after coronary interventions. J Am Coll Cardiol 1997 30 881-887. 

On one side, Doll and Peto (Doll and Peto 1981 Peto 1985 and Doll 1990) note that, for people under age 65, age-adjusted death certification rates have increased dramatically for lung cancer but stayed constant for other cancers. From tumor registry data, they conclude that age-adjusted incidence has increased dramatically for lung cancer, decreased dramatically for stomach and cervical cancer, and probably remained about the same for other nonrespiratory cancers (Doll and Peto 1981, 1211). Peto (1985, 12) says. 

Registries could offer some preliminary information about the distribution and determinants of a few reproductive and developmental outcomes (fetal death, live births, birth defects), but often additional information on exposures and the precise nature of the adverse outcomes will need to be collected. Registry data are simply not available for most fecundity-related outcomes indicative of male and female reproductive health (conception delay, early pregnancy loss). 

As of 31 December 1993, there were 18 cases of fatal pulmonary embolism in association with clozapine therapy in users aged 10-54 years. Based on the extent of use recorded in the Clozapine National Registry, the mortality rate associated with pulmonary embolism was 1 death per 3450 person years of use. This rate was about 28 times higher than that in the general population of a similar age and sex (95% Cl = 17,42). Whether pulmonary embolism can be attributed to clozapine or some characteristic(s) of its users is not clear (53). 

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