Davankov ligand exchange

V. A. Davankov, Ligand-exchange phases in Chiral Separations by HPLC, A. M. Krstulovic, Ellis Horwood Ltd., Chichester (1989) Chapter 15. 

V. A. Davankov, Ligand exchange chromatography of chiral compounds, in D. Cagniant (ed.), Complexation Chromatography, Marcel Dekker, New York, 1992, p. 197. 

An extensive review of ligand-exchange chromatography has been given by Davankov.40... 

Based on preliminary results from Helfferich130, further developments by Davankov and co-workers5 131 133 turned the principle of chelation into a powerful chiral chromatographic method by the introduction of chiral-complex-forming synlhetie resins. The technique is based on the reversible chelate complex formation of the chiral selector and the selectand (analyte) molecules with transient metal cations. The technical term is chiral ligand exchange chromatography (CLEC) reliable and complete LC separation of enantiomers of free a-amino acids and other classes of chiral compounds was made as early as 1968 131. 

Ligand Exchange Chromatography, V. A. Davankov, J. D. Navratil, H. F. Walton, Eds., CRC, Boca Raton 1988. 

Ligand exchange has proved to be very successful in the separation of several enantiomers. Davankov and Rogozhin (41) used chiral copper complexes bonded to silica. The enantiomeric separation is based essentially on the formation of diastereomeric mixed complexes with different thermodynamic stabilities. It is generally accepted that chiral discrimination proceeds via the substitution of one ligand in the coordination sphere of the metal ion. Ligand exchange technique is especially effective for the enantiomeric resolution of aminoacids, aminoacids derivatives, and hydroxy acids (42). 

Davankov VA, Navratil JD, Walton HF. Ligand Exchange Chromatography, CRC Press, Boca Raton, FL (1988). 

Davankov VA, Ligand exchange phases, in Chiral Separations by HPLC, Krstulovic A (Ed.), Ellis Horwood, Chichester, p. 447 (1989). 

Davankov, V.A. (1980) Resolution of racemates by ligand exchanges chromatography, Adv. Chromatogr. 18, 139-195. 

V. A. Davankov and A. A. Kurganov, The role of achiral sorbent matrix in chiral recognition of amino acid enantiomers in ligand-exchange chromatography, Chromatographia, 77 696 (1983). 

Another molecular rect nition force is the metal-complex formation realized in chiral ligand-exchange chromatography (CLEC). The technique was first proposed by Helf-ferich ]400] and was turned into a powerful chromatographic technique by Davankov and co-workers [8,401 j. This technique is based on a reversible chelate-complex forma-... 

V.A. Davankov. J.D. Navratil atxi H.F. Walton. Ligand Exchange Chromatography. CRC Prcs.s. 1988. 

Davankov, V. A. 30 years of chiral ligand exchange. Enantiomer, 2000, 5, 209-223. 

Kurganov, A., Davankov,V., Unger, K., Eisenbeiss, F., Kinkel, J. Unusual peak distortion in ligand-exchange chromatography of enantiomers under overloaded conditions,/. Chromatogr. A, 1994, 666, 99-110. 

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