Data ingestion

Health and Safety Factors. Phloroglucinol has low toxicity by ingestion. Prolonged severe overexposure may dismpt the thyroid function. High dust concentration may cause respiratory irritation the product is irritating to eyes and skin. Toxicity data include LD q oral (rat) = 5800 mg/kg ... 

Rosin has a low order of toxicity foUowing ingestion or skin contact. Rosin and its numerous derivatives have a number of permitted food packaging and other direct and indirect food contact uses throughout the world. Sanctioned uses appHcable in the United States are outlined in U.S. Food and Dmg Administration (U.S. FDA) Regulations (2). Material Safety Data Sheets (MSDSs) for specific rosins and thein derivatives should be consulted before thein use. 

Isocyanates. Isocyanates in general are toxic chemicals and require great care in handling. Oral ingestion of substantial quantities of isocyanates can be tolerated by the human body, but acute symptoms may develop from the inhalation of much smaller amounts. The inhalation of isocyanates presents a ha2ard for the people who work with them as weU as the people who Hve in the proximity of an isocyanate plant. Adequate control of exposure is necessary to achieve a safe working environment. The suppHers Material Safety Data Sheets (MSDS) have to be consulted for the most current information on the safe handling of isocyanates. 

Toxicity Data on Af- Vinyl-2-Pyrrolidinone. Results of a chronic inhalation study in rats warrant a review of industrial hygiene practices to assure that VP vapor concentrations are maintained at a safe level. One of the manufacturers, ISP, recommends that an appropriate workplace exposure limit be set at 0.1 ppm (vapor) (9). Additionally, normal hygienic practices and precautions are recommended, such as prompt removal from skin and avoidance of ingestion. In case of accidental eye contact, immediately flush with water for at least 15 minutes and seek medical attention. Refer to the manufacturers Material Safety Data Sheets for more detailed information. Table 3 provides some toxicity data. 

Dichloroethylene is toxic by inhalation and ingestion and can be absorbed by the skin. It has a TLV of 200 ppm (10). The odor does not provide adequate warning of dangerously high vapor concentrations. Thorough ventilation is essential whenever the solvent is used for both worker exposure and flammabihty concerns. Symptoms of exposure include narcosis, dizziness, and drowsiness. Currently no data are available on the chronic effects of exposure to low vapor concentrations over extended periods of time. 

The data from some single-dosage oral toxicity tests, expressed as LD q, are reported in Table 4. The values reported on the order of 1 g/kg or greater indicate a low acute oral toxicity. In animals, continued ingestion of chlorobenzenes over a long time can cause kidney and Hver damage. 

The ingestion of natural compounds, some of which can be identical to those administered for medicinal purposes, which have adverse effects especially in extensively reared animals, has been estimated to be about the equivalent of a 2% tax on livestock productions" For example, in the UK this would amount to about 20 million (calculated from MAFF data, 1995)S°... 

Health Hazards Information - Recommended Personal Protective Equipment Data not available Symptoms Following Exposure Irritating to skin and mucous membranes General Treatment for Exposure Data not available Toxicity by Inhalation (ThresholdLimit Value) Not pertinent Short-Term Exposure Limits Not pertinent Toxicity by Ingestion Grade 2 oral rat LDjq 3500 mg/kg Late Toxicity Not pertinent Vapor (Gas) Irritant Characteristics Not pertinent Liquid or Solid Irritant Characteristics Data not available Odor Threshold Not pertinent. 

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