Damage-associated molecular patterns

DTiUseo D, Manzi L, Velotti F. Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells. Cell Stress Chaperon 2013 18(6) 801-8. 

There is no doubt that the inflammation in the nerve tissue develops as a result of oxidative stress and mitochondrial damage [42]. It is characterized by the activation of astrocytes and microglia and by the activation of cytokines and chemokines. Very clear and instructive interpretation of the principles of neuronal inflammation was published by Hensley in terms of the influence of ROS as a major factor in the development of inflammation, autocrine and paracrine signaling neuronal network (cytokines, esicosanoids, and their interactions), plaque (Ap), damage-associated molecular patterns and NET [59]. 

Nystrom, S., et al., TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis. EMBO J, 2013. 32(1) p. 86-99. 

O Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses... 

Oxidation and Inunune Response Damage-Associated Molecular Patterns...152... 

OXIDATION AND IMMUNE RESPONSE DAMAGE-ASSOCIATED MOLECULAR PATTERNS... 

A new hypothesis links oxidized biomolecules to immune reactions via oxidation of self biomolecules generating new damage-associated molecular patterns (DAMPs) or oxidation-spedlic epitopes (OSE). Oxidation-derived DAMPs (oxDAMPs) are related to certain oxidative stress-associated disorders and can be recognized by pattern recognition receptors (PRRs) of the innate immune system, and thus activate innate or adaptive immune responses. 

FoeU, D. Wittkowski, H. VogL T. Roth, J., SlOO proteins expressed in phagocytes A novel group of damage-associated molecular pattern molecules. 

Uchida, K., Redox-derived damage-associated molecular patterns Ligand function of... 

Seong, S. and Matzinger, P. Hydrophohicity An ancient damage-associated molecular pattern that initiates innate immune responses. Nm ReyJmmunol. 4, 469 78, 2004. 

Daly, K.A., Liu, S., Agrawal, V., Brown, B.N., Johnson, S.A., Medberry, C.J., Badylak, S.F., 2012a. Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling. Biomaterials 33,91-101. 

SATO s, ST-piERRE c, BHAUMiK p, NIEMINEN J (2009), Galectins in innate immnnity dnal functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecnlar patterns (PAMPs) , Immunol Rev, 230,172-87. 

---