D phenyl

Piperacillin sodium Diethyl-d -phenyl propyl) malonate Phenprocoumon Diethylpropyl malonate Apazone... 

The addition to 2-cyclohexcnone or (fj-d-phenyl-S-penten -one gave products with d.r. 99 1. Since the configuration of 5 was not determined, a detailed interpretation of the stereoselectivity is not possible. The 1,4 addition of the chiral cuprate reagent, lithium [2-(l-dimethylamino-ethyl)phenyl](2-thienyl)cuprate, to ( )-2,2-dimethyT5-phenyl-4-penten-3-one produced predominantly one diastereomer with d.r. 99 1, while the 1,4-addition of [2-(l-dimethylaminoethyl)-phenyl]lithium to the same enone gave predominantly the opposite diastereomer (d.r. 3 97). 

Columns. ODS-silica, YMC ODS, 15 cm x 6.0 mm i.d., phenyl-bonded silica gel, YMC phenyl, 10 cm x 6.0 mm i.d. eluent, aqueous acetonitrile. Compounds, x, polycyclic aromatic hydrocarbons O, alkylbenzenes O,polychlorobenzenes +, alkanols A, alkanes 1, benzene 2, benzopyrene 3, toluene 4, heptylbenzene 5, hexachlorobenzene 6, hexanol 7, tetra-decanol 8, pentane and 9, octane. 

Answer D. Phenyl hydantoins decrease the activity of vitamin K, which is required for the y-carboxylation of coagulation factors (11, VII, IX, X), as well as proteins C and S. 

With the telluronium salts (a2), (b), (c) and (d), phenyl, benzyl, cyanomethyl and (trimethylsilyOpropargyl groups, respectively, are transferred in preference to the other groups. 

Phenyl 3,6-di-0-benzoyl-2-deoxy-a-D- Phenyl 3,6-di-0-benzoyl-2-deoxy-a-D-t/rreo-hexosid-4-ulose S [317]... 

Regis Ionic D-Phenyl Glycine (Pirklc Type 1 A) Brush , it-acccptor (R)-DNB-phenylglycine... 

Covalent D-phenyl glycine Brush , 7t-acceptor (R)-DNB-phenvlglycine... 

Problem 15.14 Synthesize (a) p-methoxybenzaldehyde from benzene (b) cyclohexylethanal by hydrobora-tion and oxidation (c) phenylacetaldehyde, using 1,3-dithiane (d) phenyl n-propyl ketone from a dithiane (e) cyclohexyl phenyl ketone from PhCOOH and RLi (/) 2-heptanone, using a cuprate ... 

Many types of chiral stationary phase are available. Pirkle columns contain a silica support with bonded aminopropyl groups used to bind a derivative of D-phenyl-glycine. These phases are relatively unstable and the selectivity coefficient is close to one. More recently, chiral separations have been performed on optically active resins or cyclodextrins (oligosaccharides) bonded to silica gel through a small hydrocarbon chain linker (Fig. 3.11). These cyclodextrins possess an internal cavity that is hydro-phobic while the external part is hydrophilic. These molecules allow the selective inclusion of a great variety of compounds that can form diastereoisomers at the surface of the chiral phase leading to reversible complexes. 

Platin Bis-[d phenyl-methyl-phosphan]-chloro-trifluoro-mcthyl- XII l/9a, 710 (FjC-CO-PtLj-CI, A)... 

Isomers of BHA Mixture of 2-BHA and 3-BHA 5-yu.m A-aminopropyl packing, modified with /V-3,5-dinitroben-zoyl derevative of D-phenyl-glycine... 

Since ethyl benzoate C has a carbonyl stretch at 1725 cm 1, the likely product is D, phenyl propionate. This is confirmed by the NMR spectrum, which has the methylene group as a quartet at 2.425. This chemical shift is typical for a methylene group next to an ester carbonyl but is much too high field for the -CH2-group in ethoxy ester C, which comes at about 3.65. 

In 1994 Shea et al. reported the preparation of gel-like imprinted polymers with enantioselective esterolytic activity toward the Boc-D-phenyl-alanine p-nitrophenol ester (28) [19]. The polymers were prepared using a covalent approach, rather than metal complexes or non-covalent interactions, by attaching the catalytic phenol-imidazole unit to the TSA phosphonate via ester linkage (29). The imprinted polymer, containing the catalytic unit (30), showed little selectivity toward the D-enantiomer used for the imprinting. 

PNU-95666E (116) is a selective and high-affinity artificial agonist at the dopamine D2 receptor subtype and is a potential agent for treating Parkinson s disease. The synthesis of the enantiomerically pure tricyclic structure (186) was achieved by PIFA-induced oxidative cyclization of 185, starting from D-phenyl-alanine [140] (Scheme 49). This methodology was applied to a multikilo scale synthesis. 

Figure 12. Chromatograms of the resolution of (a) the ansa-zirconocene derivative, (b) the adamantan derivative, (c) 2,2 -dihydroxy-6,6 -dimethylbiphenyl, (d) phenyl vinyl sulfoxide, (e) abscisic acid, and (f) laudanosine. Column, 25 x 0.46 cm (i.d.) flow rate, 0.5 ml/min. Chromatograms (a) and (e) are reproduced, with permission, from Ref. 61 (Copyright 1996, Chemical Society of Japan) and Ref. 62 (Copyright 1988, Elsevier Science B.V.),...

Nateglinide has an -configured chirality centre and is derived from d-phenyl-alanine. The substituted trans-configured cyclohexyl residue is achiral since it has a plane of symmetry. 

D-Phenyl propionates of methyl esters of racemic hydroxy acids were prepared by Hammarstrom and Hamberg [190] and used for the separation of enantiomers of these compounds on QF-1. The separation was successful with methyl 3-, 15-, 16- and-17-hydroxyoctadecanoates, whereas diastereoisomers of methyl 4-, 7- and 13-hydroxyocta-decanoic acids were not separated. The derivatives were prepared at room temperature reaction of the ester of the hydroxy acid with D-2-phenylpropionyl chloride in the presence of pyridine for 2 h. 

Boron, trlhydro(tetrahydro-1-methyl-3,3-d phenyl-1 H,3H-pyrrolo-... 

Consequently, although the hydantoinase process has been successfully used for producing 100% D-phenyl- and D-p-hydroxy-phenylglycine [9], only 50% of the... 

BSC-REFINE D PHENYL-SULFONYL CHLORIDE RCRA WASTE NUMBER U020... 

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