D-Glycerate kinase

Carbohydrate D-Glycerate kinase deficiency D-Glyceric acid TT... 

Fig. 15.2. Pathways of fructose metabolism. 15.4, Fructose-1-phosphate aldolase 15.5, fructose-1,6-diphosphatase 15.7, D-glycerate kinase. F-l-P, Fructose-1-phosphate F-6-P, fructose-6-phosphate F-l,6-DiP, fructose-1,6-diphosphate Glc-6-F, glucose-6-phosphate ATP, adenosine triphosphate ADP, adenosine diphosphate...

Table 15.7. D-Glyceric acidemia (D-glycerate kinase deficiency) ...

However, recent work has tended to cast some doubt upon both the schemes of Sallach and of Ichihara and Greenberg. Lamprecht et td. 16) reported that the product formed by the D-glycerate kinase actually is 2-... 

Harlos K, Vas M, Blake CF. Crystal structure of the binary complex of pig muscle phosphogycerate kinase and its substrate 3-phospho-D-glycerate. Proteins Struct Funct Genet 1992 12 133-144. 

A series of conformationally-restrained phosphonate analogues, e.g. (209), (210), and (211), of D-glyceric acid 1,3-bisphosphate (208) have been synthesised as potential inhibitors of phosphoglycerate kinase (3-PGK). A number of... 

Fig. 1. Main routes involved in the synthesis and interconversion of glycine and serine in plants. The various steps are numbered, and the necessary enzymes are as follows 1, glycolate oxidase, E.C. 1.1.3.1 2, aminotransferases, serine, E.C. 2.6.1.45, and glutamate, E.C. 2.6.1.4, glyoxylate aminotransferases 3, enzyme complex in mitochondria (see Fig. 2) 4, serine-glyoxylate aminotransferase, E.C. 2.6.1.45 5, glycerate dehydrogenase, E.C. 1.1.1.29 6, glycerate kinase E.C. 2.7.1.31 7, D-3-phosphoglycerate phosphatase, E.C. 3.1.3.38 8, d-3-phosphoglycerate dehydrogenase, E.C. 1.1.1.95 9, phosphoserine aminotransferase, E.C. 2.6.1.52 10, phosphoserine phosphatase, E.C. 3.1.3.3 11, serine hydroxymethyltransferase E.C. 2.1.2.1 12, nonenzymatic decarboxylation 13, formyl tetrahydrofolate synthetase, E.C. 6.3.4.3 14, isocitrate iyase, E.C. 4.1.3.1.

The carboxyl group of the 3-phospho-D-glyceric acid is phosphorylated by ATP (reaction 4 of Fig. 10.3), catalyzed by 3-phospho-D-glyceric acid kinase, pro-... 

D. Serine is synthesized from glucose. The pathway branches from glycolysis at phospho-glyceric acid, which is reduced, transaminated, and dephosphoiylated by phosphoserine phosphatase. Pyruvate kinase is a glycolytic enzyme that functions beyond the branch point for serine synthesis. 

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