D-Aspartic acid

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. 

NMDA (iV-methyl-D-aspartic acid) is a synthetic derivative of aspartic acid and represents the prototypical agonist at the NMDA receptors for which the latter were named. 

Gillard, R. D., A. M. Pollard, R. A. Sutton, and D. K. Whittaker (1990), An improved method for age at death determination from the measurement of D-aspartic acid in dental collagen, Archaeometry 32, 61-70. 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

D-Aspartic acid 16 Apoxycillin Antibacterial Decarboxylation Pseudomonas dacunhae Immobilized cells [10]... 

H. Yokoyama, N. Mori, N. Kasai, T. Matsue, I. Uchida, N. Kobayashi, N. Tsuchihashi, T. Yoshimura, M. Hiramatsu, and S.I. Niwa, Direct and continuous monitoring of intrahippocampal nitric oxide (NO) by an NO sensor in freely moving rat after N-methyl-D-aspartic acid injection. Denki Kagaku 63, 1167-1170 (1995). 

The main building block of PEDC (1 -phenyl-2-[(S)-l-aminoethyl] -N,N -di-ethylcyclopropanecarboxamide), a potent NDMA (N -methyl-D-aspartic acid) receptor antagonist of a cyclopropane structure, N -benzyl-C-cyclopropyl nitrone... 

D-Aspartic acid, systematic name, formula, and molecular weight, 2 558t DL-Aspartic acid, systematic name, formula, and molecular weight,... 

Figure 2.9. Amino acid sequences of human defensins. The conserved positions of six cysteine residues are shown in hatched boxes. Abbreviations A, alanine C, cysteine D, aspartic acid E, glutamic acid F, phenylalanine G, glycine H, histidine I, isoleucine K, lysine L, leucine M, methionine N, asparagine P, proline Q, glutamic acid R, arginine S, serine T, threonine V, valine W, tryptophan Y, tyrosine.

Fic. 1. The amino acid sequences of calf histones H2A (Yeoman et al., 1972 Sau-tiere et al., 1974) and H2B (Iwai et al., 1972). A one-letter code is used A, alanine R, arginine N, asparagine D, aspartic acid C, cysteine E, glutamic acid Q, glutamine ... 

Stoof JC, Booji J, Drukarch B. (1992). Amantadine as /V-methyl-D-aspartic acid receptor antagonist new possibilities for therapeutic applications Clin Neurol Neurosurg. 94(suppl) S4-6. 

By the second method Schulze and Bosshard prepared d-leucine and 1-glutamic acid, and Engel prepared d-aspartic acid. Menozzi and Appiani also separated glutamic acid by this method. In all these cases the mould Penicillium glaucum was used to effect the separation. 

The foundation for the configuration of these amino acids will be obtained if a-amino-y8-chloropropionic acid can be converted into aspartic acid, the configuration of which is known from its relationship to malic acid, (d-aspartic acid is converted into d-malic acid by nitrous acid.) The configuration of malic acid can be referred to that of tartaric acid and thence to d-glucose. 

Amino acid side chains at the positions X, Y, Z, -Y,-X, and —Z (illustrated in Fig. 29) of EF hands and other calcium-binding regions are listed. D, Aspartic acid E, glutamic acid N, asparagine S, serine T, threonine Ox, main-chain carbonyl Wa, water Ph, phosphate O -, a number of intervening amino acids. 

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